Evidence map›Paper›PMID 26812691›Full record

ArticleThe Journal of clinical endocrinology and metabolism2016

Physical Activity and the Risk of Primary Hyperparathyroidism.

Anand Vaidya, Gary C Curhan, Julie M Paik, Molin Wang, Eric N Taylor

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 73 citations in OpenAlex.

  1. Body Size and the Risk of Primary Hyperparathyroidism in Women: A Cohort Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017
    Trial
  2. Article
  3. Review
  4. Review
  5. Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels.International journal of molecular sciences · 2021
    Review
  6. Article
  7. Review
  8. Primary Hyperparathyroidism.The Journal of clinical endocrinology and metabolism · 2018
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Anand VaidyaDivision of Endocrinology, Diabetes, and Hypertension (A.V.), Division of Renal Medicine (G.C.C., J.M.P.), Channing Division of Network Medicine (G.C.C., J.M.P., E.N.T.), Brigham and Women's Hospital (A.V., G.C.C., J.M.P., E.N.T.), Boston, Massachusetts; Harvard Medical School (A.V., J.M.P.), Boston, Massachusetts; Department of Epidemiology (G.C.C. J.M.P., M.W.), Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Division of Nephrology and Transplantation (E.N.T.), Maine Medical Center, Portland, Maine 02115.
Gary C CurhanDivision of Endocrinology, Diabetes, and Hypertension (A.V.), Division of Renal Medicine (G.C.C., J.M.P.), Channing Division of Network Medicine (G.C.C., J.M.P., E.N.T.), Brigham and Women's Hospital (A.V., G.C.C., J.M.P., E.N.T.), Boston, Massachusetts; Harvard Medical School (A.V., J.M.P.), Boston, Massachusetts; Department of Epidemiology (G.C.C. J.M.P., M.W.), Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Division of Nephrology and Transplantation (E.N.T.), Maine Medical Center, Portland, Maine 02115.
Julie M PaikDivision of Endocrinology, Diabetes, and Hypertension (A.V.), Division of Renal Medicine (G.C.C., J.M.P.), Channing Division of Network Medicine (G.C.C., J.M.P., E.N.T.), Brigham and Women's Hospital (A.V., G.C.C., J.M.P., E.N.T.), Boston, Massachusetts; Harvard Medical School (A.V., J.M.P.), Boston, Massachusetts; Department of Epidemiology (G.C.C. J.M.P., M.W.), Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Division of Nephrology and Transplantation (E.N.T.), Maine Medical Center, Portland, Maine 02115.
Molin WangDivision of Endocrinology, Diabetes, and Hypertension (A.V.), Division of Renal Medicine (G.C.C., J.M.P.), Channing Division of Network Medicine (G.C.C., J.M.P., E.N.T.), Brigham and Women's Hospital (A.V., G.C.C., J.M.P., E.N.T.), Boston, Massachusetts; Harvard Medical School (A.V., J.M.P.), Boston, Massachusetts; Department of Epidemiology (G.C.C. J.M.P., M.W.), Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Division of Nephrology and Transplantation (E.N.T.), Maine Medical Center, Portland, Maine 02115.
Eric N TaylorDivision of Endocrinology, Diabetes, and Hypertension (A.V.), Division of Renal Medicine (G.C.C., J.M.P.), Channing Division of Network Medicine (G.C.C., J.M.P., E.N.T.), Brigham and Women's Hospital (A.V., G.C.C., J.M.P., E.N.T.), Boston, Massachusetts; Harvard Medical School (A.V., J.M.P.), Boston, Massachusetts; Department of Epidemiology (G.C.C. J.M.P., M.W.), Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Division of Nephrology and Transplantation (E.N.T.), Maine Medical Center, Portland, Maine 02115.
Harvard University · USBrigham and Women's Hospital · USMaine Medical Center · US

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Interactions Between Adrenal and Parathyroid Hormones in Human HealthR01DK107407 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI VAIDYA, ANAND · 2015 to 2019
$2.5M
Risk Factors for and Tissue Biomarker Expression in Primary HyperparathyroidismR01DK099739 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI TAYLOR, ERIC N · 2014 to 2017
$1.7M
Sex-related differences in incidence rates of nephrolithiasisK24DK091417 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI CURHAN, GARY C. · 2011 to 2020
$1.5M
Novel Risk Factors for Vertebral Fractures in Health and Chronic Kidney DiseaseK23DK100447 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI PAIK, JULIE · 2013 to 2017
$938k
Vitamin D and Hormonal Mechanisms of Cardiovascular Disease in ObesityK23HL111771 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI VAIDYA, ANAND · 2012 to 2016
$805k
Doris Duke Charitable Foundation 2015085NCI NIH HHS P01 CA087969NCI NIH HHS UM1 CA186107NHLBI NIH HHS K23 HL111771NHLBI NIH HHS L30 HL104553NIDDK NIH HHS K23 DK100447NIDDK NIH HHS K24 DK091417NIDDK NIH HHS R01 DK099739NIDDK NIH HHS R01 DK107407
6 · The paper itself

Abstract

contextPrimary hyperparathyroidism (P-HPTH) is relatively common and predominantly affects women. Prior studies have shown that physical activity (PA) can lower PTH levels.

objectiveOur objective was to evaluate the hypothesis that lower PA is a risk factor for developing P-HPTH. DESIGN, SETTING, AND

participantsThis prospective cohort study included 69 621 female participants in the Nurses' Health Study I followed for 22 years. EXPOSURES: PA and other dietary and demographic exposures were quantified via detailed, and validated, biennial questionnaires. OUTCOMES: Incident P-HPTH was confirmed by medical record review after initial assessment by questionnaire. Adjusted Cox proportional hazards models were used to evaluate whether PA was an independent risk factor for developing P-HPTH. We also evaluated the risk of developing P-HPTH when combining low PA (<16 metabolic equivalent hours/week) with a previously identified independent risk factor for developing P-HPTH: low calcium intake (<800 mg/day). The relation between PA and PTH levels was evaluated in 625 participants.

resultsWe confirmed 302 incident cases of P-HPTH during 1 474 993 person-years of follow-up. Participants in the highest quintile (Q) of PA had a 50% lower risk of developing P-HPTH: age-adjusted relative risks and 95% confidence intervals for incident P-HPTH by lowest to highest of PA were Q1 = 1.0 (reference); Q2 = 0.83 (0.60–1.15); Q3 = 0.84 (0.61–1.15); Q4 = 0.50 (0.34–0.74); Q5 = 0.50 (0.35–0.73); P for trend <.001. Extensive multivariable adjustments did not materially change these findings. The adjusted relative risk for developing P-HPTH among participants with the combination lower PA and lower calcium intake was 2.37-fold (1.60–3.51) higher than in participants with higher PA and higher calcium intake. PA was inversely correlated with serum PTH (ρ = −0.09, P = .03); the mean adjusted serum PTH in Q 2–5 of PA was lower than in Q 1 (36.3 vs 39.1 pg/mL, P = .02).

conclusionLow physical activity may be a modifiable risk factor for developing P-HPTH in women.

Indexed as

AdultExerciseFemaleHumansHyperparathyroidism, PrimaryIncidenceMaineMiddle AgedProspective StudiesRisk Factors

Identifiers

PMID26812691
PMCPMC4880164
OpenAlexW2270382926

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.