ArticleNeuroImage2016
Sleep reverts changes in human gray and white matter caused by wake-dependent training.
Article in NeuroImage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Association between weekend recovery sleep and risk of incident dementia: a prospective cohort study in the UK Biobank.Journal of neurology · 2025Article
- Perivascular space diffusivity and brain microstructural measures are associated with circadian time and sleep quality.Journal of sleep research · 2024Article
- Brain ventricle and choroid plexus morphology as predictor of treatment response in major depression: Findings from the EMBARC study.Brain, behavior, & immunity - health · 2024Article
- Microstructural dynamics of motor learning and sleep-dependent consolidation: A diffusion imaging study.iScience · 2023Article
- Brain Ventricle and Choroid Plexus Morphology as Predictor of Treatment Response: Findings from the EMBARC Study.Research square · 2023Article
- Overnight Abstinence Is Associated With Smaller Secondary Somatosensory Cortical Volumes and Higher Somatosensory-Motor Cortical Functional Connectivity in Cigarette Smokers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022Article
- The glymphatic system: implications for drugs for central nervous system diseases.Nature reviews. Drug discovery · 2022Review
- The glymphatic system: Current understanding and modeling.iScience · 2022Review
- Evidence for widespread alterations in cortical microstructure after 32 h of sleep deprivation.Translational psychiatry · 2022Article
- General additive models address statistical issues in diffusion MRI: An example with clinically anxious adolescents.NeuroImage. Clinical · 2022Article
- Extended Visual Sequence Learning Leaves a Local Trace in the Spontaneous EEG.Frontiers in neuroscience · 2021Article
- Brain Structural and Functional Connectivity: A Review of Combined Works of Diffusion Magnetic Resonance Imaging and Electro-Encephalography.Frontiers in human neuroscience · 2021Review
- Alteration of Brain Gray Matter Density After 24 h of Sleep Deprivation in Healthy Adults.Frontiers in neuroscience · 2020Article
- Current Understanding of Central Nervous System Drainage Systems: Implications in the Context of Neurodegenerative Diseases.Current neuropharmacology · 2020Review
- Article
- Apparent diffusion coefficient changes in human brain during sleep - Does it inform on the existence of a glymphatic system?NeuroImage · 2019Article
- Dreaming in NREM Sleep: A High-Density EEG Study of Slow Waves and Spindles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Obstructive sleep apnoea and Alzheimer's disease: In search of shared pathomechanisms.Neuroscience and biobehavioral reviews · 2018Review
- Local and Widespread Slow Waves in Stable NREM Sleep: Evidence for Distinct Regulation Mechanisms.Frontiers in human neuroscience · 2018Article
- Depressive Symptom Dimensions and Their Association with Hippocampal and Entorhinal Cortex Volumes in Community Dwelling Older Adults.Frontiers in aging neuroscience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
Abstract
Learning leads to rapid microstructural changes in gray (GM) and white (WM) matter. Do these changes continue to accumulate if task training continues, and can they be reverted by sleep? We addressed these questions by combining structural and diffusion weighted MRI and high-density EEG in 16 subjects studied during the physiological sleep/wake cycle, after 12 h and 24 h of intense practice in two different tasks, and after post-training sleep. Compared to baseline wake, 12 h of training led to a decline in cortical mean diffusivity. The decrease became even more significant after 24 h of task practice combined with sleep deprivation. Prolonged practice also resulted in decreased ventricular volume and increased GM and WM subcortical volumes. All changes reverted after recovery sleep. Moreover, these structural alterations predicted cognitive performance at the individual level, suggesting that sleep's ability to counteract performance deficits is linked to its effects on the brain microstructure. The cellular mechanisms that account for the structural effects of sleep are unknown, but they may be linked to its role in promoting the production of cerebrospinal fluid and the decrease in synapse size and strength, as well as to its recently discovered ability to enhance the extracellular space and the clearance of brain metabolites.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.