Evidence map›Paper›PMID 26812644›Full record

ArticlePloS one2016

Klebsiella pneumoniae Is Able to Trigger Epithelial-Mesenchymal Transition Process in Cultured Airway Epithelial Cells.

Laura Leone, Francesca Mazzetta, Daniela Martinelli, Sabatino Valente, Maurizio Alimandi, Salvatore Raffa, Iolanda Santino

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Review
  3. Frontiers in microbiology · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Persistence Infection of TGEV PromotesInternational journal of molecular sciences · 2022
    Article
  10. Airway Epithelial Cells Differentially Adapt Their Iron Metabolism to Infection WithFrontiers in cellular and infection microbiology · 2022
    Article
  11. HypervirulentIDCases · 2021
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Laura LeoneDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Francesca MazzettaDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Daniela MartinelliMicrobiology Unit, Azienda Ospedaliera Sant'Andrea, Rome, Italy.
Sabatino ValenteDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Maurizio AlimandiDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Salvatore RaffaDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Iolanda SantinoDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · ITAzienda Ospedaliera Sant'Andrea · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability of some bacterial pathogens to activate Epithelial-Mesenchymal Transition normally is a consequence of the persistence of a local chronic inflammatory response or depends on a direct interaction of the pathogens with the host epithelial cells. In this study we monitored the abilities of the K. pneumoniae to activate the expression of genes related to EMT-like processes and the occurrence of phenotypic changes in airway epithelial cells during the early steps of cell infection. We describe changes in the production of intracellular reactive oxygen species and increased HIF-1α mRNA expression in cells exposed to K. pneumoniae infection. We also describe the upregulation of a set of transcription factors implicated in the EMT processes, such as Twist, Snail and ZEB, indicating that the morphological changes of epithelial cells already appreciable after few hours from the K. pneumoniae infection are tightly regulated by the activation of transcriptional pathways, driving epithelial cells to EMT. These effects appear to be effectively counteracted by resveratrol, an antioxidant that is able to exert a sustained scavenging of the intracellular ROS. This is the first report indicating that strains of K. pneumoniae may promote EMT-like programs through direct interaction with epithelial cells without the involvement of inflammatory cells.

Indexed as

Epithelial-Mesenchymal TransitionCell Line, TumorCell SurvivalEpithelial CellsHomeodomain ProteinsHumansHypoxia-Inducible Factor 1, alpha SubunitKlebsiella pneumoniaeMicroscopy, FluorescencePhenotypeReactive Oxygen SpeciesReal-Time Polymerase Chain ReactionSnail Family Transcription FactorsTranscription FactorsTwist-Related Protein 1Up-RegulationHomeodomain ProteinsHypoxia-Inducible Factor 1, alpha SubunitReactive Oxygen SpeciesSnail Family Transcription FactorsTranscription FactorsTwist-Related Protein 1ZEB1 protein, humanZinc Finger E-box-Binding Homeobox 1

Identifiers

PMID26812644
PMCPMC4727911
OpenAlexW2415839083

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.