ArticleChemical communications (Cambridge, England)2016
DNA-based control of protein activity.
Article in Chemical communications (Cambridge, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Physical stimuli-responsive DNA hydrogels: design, fabrication strategies, and biomedical applications.Journal of nanobiotechnology · 2025Review
- DNA-Regulated Multi-Protein Complement Control.Journal of the American Chemical Society · 2024Article
- Exploring Emergent Properties in Enzymatic Reaction Networks: Design and Control of Dynamic Functional Systems.Chemical reviews · 2024Review
- Regulating Chemokine-Receptor Interactions through the Site-Specific Bioorthogonal Conjugation of Photoresponsive DNA Strands.Bioconjugate chemistry · 2023Article
- Synthetic Antigen-Conjugated DNA Systems for Antibody Detection and Characterization.ACS sensors · 2023Review
- DNA Strand Displacement Driven by Host-Guest Interactions.Journal of the American Chemical Society · 2022Article
- The role of DNA nanostructures in the catalytic properties of an allosterically regulated protease.Science advances · 2022Article
- Dynamic Protease Activation on a Multimeric Synthetic Protein Scaffold via Adaptable DNA-Based Recruitment Domains.Angewandte Chemie (International ed. in English) · 2021Article
- Proximity-induced caspase-9 activation on a DNA origami-based synthetic apoptosome.Nature catalysis · 2020Article
- Crystal structure of the Wheat dwarf virus Rep domain.Acta crystallographica. Section F, Structural biology communications · 2019Article
- Manipulating Enzymes Properties with DNA Nanostructures.Molecules (Basel, Switzerland) · 2019Review
- Accelerating DNA-Based Computing on a Supramolecular Polymer.Journal of the American Chemical Society · 2018Article
- Controlling protein activity by dynamic recruitment on a supramolecular polymer platform.Nature communications · 2018Article
- Incorporation of native antibodies and Fc-fusion proteins on DNA nanostructures via a modular conjugation strategy.Chemical communications (Cambridge, England) · 2017Article
- Sequence-Directed Covalent Protein-DNA Linkages in a Single Step Using HUH-Tags.Journal of the American Chemical Society · 2017Article
- DNA-Based Enzyme Reactors and Systems.Nanomaterials (Basel, Switzerland) · 2016Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
DNA has emerged as a highly versatile construction material for nanometer-sized structures and sophisticated molecular machines and circuits. The successful application of nucleic acid based systems greatly relies on their ability to autonomously sense and act on their environment. In this feature article, the development of DNA-based strategies to dynamically control protein activity via oligonucleotide triggers is discussed. Depending on the desired application, protein activity can be controlled by directly conjugating them to an oligonucleotide handle, or expressing them as a fusion protein with DNA binding motifs. To control proteins without modifying them chemically or genetically, multivalent ligands and aptamers that reversibly inhibit their function provide valuable tools to regulate proteins in a noncovalent manner. The goal of this feature article is to give an overview of strategies developed to control protein activity via oligonucleotide-based triggers, as well as hurdles yet to be taken to obtain fully autonomous systems that interrogate, process and act on their environments by means of DNA-based protein control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.