Evidence map›Paper›PMID 26812510›Full record

Trial reportThe journal of nutrition, health & aging2016

Association of Long-Term Dietary Fat Intake, Exercise, and Weight with Later Cognitive Function in the Finnish Diabetes Prevention Study.

J Lehtisalo, J Lindström, T Ngandu, M Kivipelto, S Ahtiluoto, P Ilanne-Parikka, S Keinänen-Kiukaanniemi, J G Eriksson, M Uusitupa, J Tuomilehto and 2 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journal of nutrition, health & aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.

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  18. Lifestyle Choices and Brain Health.Frontiers in medicine · 2019
    Review
  19. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 6 countries.

J LehtisaloJenni Lehtisalo, Chronic Disease Prevention Unit, Department of Health, National Institute for Health and Welfare (THL), P.O.Box 30 FI-00271 Helsinki, Finland, Phone: +358 29 524 8573, email: jenni.lehtisalo@thl.fi.
J Lindström
T Ngandu
M Kivipelto
S Ahtiluoto
P Ilanne-Parikka
S Keinänen-Kiukaanniemi
J G Eriksson
M Uusitupa
J Tuomilehto
J Luchsinger
Finnish Diabetes Prevention Study
Finnish Institute for Health and Welfare · FIUniversity of Eastern Finland · FIColumbia University Irving Medical Center · USHelsinki University Hospital · FIKing Abdulaziz University · SAOulu University Hospital · FITampere University · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate associations of long-term nutrient intake, physical activity and obesity with later cognitive function among the participants in the Finnish Diabetes Prevention Study, in which a lifestyle intervention was successful in diabetes prevention.

designAn active lifestyle intervention phase during middle age (mean duration 4 years) and extended follow-up (additional 9 years) with annual lifestyle measurements, followed by an ancillary cognition assessment.

setting5 research centers in Finland.

participantsOf the 522 middle-aged, overweight participants with impaired glucose tolerance recruited to the study, 364 (70%) participated in the cognition assessment (mean age 68 years). MEASUREMENTS: A cognitive assessment was executed with the CERAD test battery and the Trail Making Test A on average 13 years after baseline. Lifestyle measurements included annual clinical measurements, food records, and exercise questionnaires during both the intervention and follow-up phase.

resultsLower intake of total fat (p=0.021) and saturated fatty acids (p=0.010), and frequent physical activity (p=0.040) during the whole study period were associated with better cognitive performance. Higher BMI (p=0.012) and waist circumference (p=0.012) were also associated with worse performance, but weight reduction prior to the cognition assessment predicted worse performance as well (decrease vs. increase, p=0.008 for BMI and p=0.002 for waist).

conclusionsLong-term dietary fat intake, BMI, and waist circumference have an inverse association with cognitive function in later life among people with IGT. However, decreases in BMI and waist prior to cognitive assessment are associated with worse cognitive performance, which could be explained by reverse causality.

Indexed as

Body Mass IndexCognitionDietExerciseAgedBody WeightCognition DisordersDementiaDiabetes MellitusDietary FatsEnergy IntakeFeeding BehaviorFemaleFinlandGlucose IntoleranceHumansDietary Fats

Identifiers

PMID26812510
PMCPMC12877625
OpenAlexW921616494

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.