ArticleJournal of natural products2016
Oxaspirol B with p97 Inhibitory Activity and Other Oxaspirols from Lecythophora sp. FL1375 and FL1031, Endolichenic Fungi Inhabiting Parmotrema tinctorum and Cladonia evansii.
Article in Journal of natural products, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Endolichenic Fungi: A Promising Medicinal Microbial Resource to Discover Bioactive Natural Molecules-An Update.Journal of fungi (Basel, Switzerland) · 2024Review
- A targeted covalent inhibitor of p97 with proteome-wide selectivity.Acta pharmaceutica Sinica. B · 2022Article
- The metabolite 5-methyl-1,3-benzenediol and its derivative methyl-2,4-dihydroxy-6-methylbenzoate from the lichen3 Biotech · 2021Article
- New phenol and chromone derivatives from the endolichenic fungusRSC advances · 2021Article
- A covalent p97/VCP ATPase inhibitor can overcome resistance to CB-5083 and NMS-873 in colorectal cancer cells.European journal of medicinal chemistry · 2021Article
- Teratopyrones A-C, Dimeric Naphtho-γ-Pyrones and Other Metabolites fromMolecules (Basel, Switzerland) · 2020Article
- Characterization of Eight Novel Spiroleptosphols fromMolecules (Basel, Switzerland) · 2019Article
- Article
- Fungal Identification Using Molecular Tools: A Primer for the Natural Products Research Community.Journal of natural products · 2017Review
- VCP inhibitors induce endoplasmic reticulum stress, cause cell cycle arrest, trigger caspase-mediated cell death and synergistically kill ovarian cancer cells in combination with Salubrinal.Molecular oncology · 2016Article
- Targeting p97 to Disrupt Protein Homeostasis in Cancer.Frontiers in oncology · 2016Review
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Authors and funding
11 authors at 2 institutions in 3 countries.
Funding
Abstract
A new metabolite, oxaspirol D (4), together with oxaspirols B (2) and C (3) were isolated from Lecythophora sp. FL1375, an endolichenic fungus isolated from Parmotrema tinctorum, whereas Lecythophora sp. FL1031 inhabiting the lichen Cladonia evansii afforded oxaspirols A (1), B (2), and C (3). Of these, oxaspirol B (2) showed moderate p97 ATPase inhibitory activity. A detailed characterization of all oxaspirols was undertaken because structures proposed for known oxaspirols have involved incomplete assignments of NMR spectroscopic data leading only to their planar structures. Thus, the naturally occurring isomeric mixture (2a and 2b) of oxaspirol B was separated as their diacetates (5a and 5b) and the structures and absolute configurations of 1, 2a, 2b, 3, and 4 were determined by the application of spectroscopic techniques including two-dimensional NMR and the modified Mosher's ester method. Oxaspirol B (2) and its diacetates 5a and 5b were evaluated for their ATPase inhibitory activities of p97, p97 mutants, and other ATP-utilizing enzymes, and only 2 was found to be active, indicating the requirement of some structural features in oxaspirols for their activity. Additional biochemical and cellular assays suggested that 2 was a reversible, non-ATP competitive, and specific inhibitor of p97.
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Registered trials
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