Evidence map›Paper›PMID 26812193›Full record

ArticleNeurotoxicology2017

Inflammatory and oxidative stress-related effects associated with neurotoxicity are maintained after exclusively prenatal trichloroethylene exposure.

Sarah J Blossom, Stepan B Melnyk, Ming Li, William D Wessinger, Craig A Cooney

Abstract read
In one paragraph

Article in Neurotoxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Sarah J BlossomDepartment of Pediatrics, University of Arkansas for Medical Sciences, College of Medicine, Arkansas Children's Hospital Research Institute, 13 Children's Way, Little Rock, AR 72202, USA. Electronic address: blossomsarah@uams.edu.
Stepan B MelnykDepartment of Pediatrics, University of Arkansas for Medical Sciences, College of Medicine, Arkansas Children's Hospital Research Institute, 13 Children's Way, Little Rock, AR 72202, USA.
Ming LiDepartment of Pediatrics, University of Arkansas for Medical Sciences, College of Medicine, Arkansas Children's Hospital Research Institute, 13 Children's Way, Little Rock, AR 72202, USA.
William D WessingerDepartment of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, College of Medicine, 4301 West Markham St., Little Rock, AR 72205, USA.
Craig A CooneyDepartment of Research and Development, Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA.
University of Arkansas for Medical Sciences · USArkansas Children's Hospital · USCentral Arkansas Veterans Healthcare System · US

Funding

CD4+ T cell-mediated neurotoxicity with continuous trichloroethylene exposureK02ES024387 · NIEHS · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI BLOSSOM, SARAH J · 2014 to 2018
$674k
Neuroimmune dysregulation with developmental exposure to trichloroethyleneR21ES017311 · NIEHS · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI BLOSSOM, SARAH J · 2010 to 2011
$402k
NIEHS NIH HHS K02 ES024387NIEHS NIH HHS R21 ES017311
6 · The paper itself

Abstract

Trichloroethylene (TCE) is a widespread environmental toxicant with immunotoxic and neurotoxic potential. Previous studies have shown that continuous developmental exposure to TCE encompassing gestation and early life as well as postnatal only exposure in the drinking water of MRL+/+ mice promoted CD4

Indexed as

Anesthetics, InhalationAnimalsCD4-Positive T-LymphocytesCytokinesDose-Response Relationship, DrugEncephalitisExploratory BehaviorFemaleIsofluraneMaleMiceMice, TransgenicNeurotoxicity SyndromesOxidative StressPregnancyPrenatal Exposure Delayed Effects3-nitrotyrosineAnesthetics, InhalationCytokinesGpr84 protein, mouseIsofluraneReceptors, G-Protein-CoupledTrichloroethyleneTyrosineBehaviorCerebellumGlutathioneInflammationRedoxTrichloroethylene oxidative stress

Identifiers

PMID26812193
PMCPMC4958597
OpenAlexW2256313449

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.