Evidence map›Paper›PMID 26812158›Full record

ArticleEndocrinology2016

Metabolic Benefit of Chronic Caloric Restriction and Activation of Hypothalamic AGRP/NPY Neurons in Male Mice Is Independent of Ghrelin.

Nicole H Rogers, Heidi Walsh, Oscar Alvarez-Garcia, Seongjoon Park, Bruce Gaylinn, Michael O Thorner, Roy G Smith

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. The Role of Ghrelin and Ghrelin Signaling in Aging.International journal of molecular sciences · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Nicole H RogersDepartment of Metabolism and Aging (N.H.R., H.W., O.A.-G., S.P., R.G.S.), The Scripps Research Institute Florida, Jupiter, Florida 33458; and Division of Endocrinology and Metabolism (B.G., M.O.T.), Department of Medicine, University of Virginia, Charlottesville, Virginia 22908.
Heidi WalshDepartment of Metabolism and Aging (N.H.R., H.W., O.A.-G., S.P., R.G.S.), The Scripps Research Institute Florida, Jupiter, Florida 33458; and Division of Endocrinology and Metabolism (B.G., M.O.T.), Department of Medicine, University of Virginia, Charlottesville, Virginia 22908.
Oscar Alvarez-GarciaDepartment of Metabolism and Aging (N.H.R., H.W., O.A.-G., S.P., R.G.S.), The Scripps Research Institute Florida, Jupiter, Florida 33458; and Division of Endocrinology and Metabolism (B.G., M.O.T.), Department of Medicine, University of Virginia, Charlottesville, Virginia 22908.
Seongjoon ParkDepartment of Metabolism and Aging (N.H.R., H.W., O.A.-G., S.P., R.G.S.), The Scripps Research Institute Florida, Jupiter, Florida 33458; and Division of Endocrinology and Metabolism (B.G., M.O.T.), Department of Medicine, University of Virginia, Charlottesville, Virginia 22908.
Bruce GaylinnDepartment of Metabolism and Aging (N.H.R., H.W., O.A.-G., S.P., R.G.S.), The Scripps Research Institute Florida, Jupiter, Florida 33458; and Division of Endocrinology and Metabolism (B.G., M.O.T.), Department of Medicine, University of Virginia, Charlottesville, Virginia 22908.
Michael O ThornerDepartment of Metabolism and Aging (N.H.R., H.W., O.A.-G., S.P., R.G.S.), The Scripps Research Institute Florida, Jupiter, Florida 33458; and Division of Endocrinology and Metabolism (B.G., M.O.T.), Department of Medicine, University of Virginia, Charlottesville, Virginia 22908.
Roy G SmithDepartment of Metabolism and Aging (N.H.R., H.W., O.A.-G., S.P., R.G.S.), The Scripps Research Institute Florida, Jupiter, Florida 33458; and Division of Endocrinology and Metabolism (B.G., M.O.T.), Department of Medicine, University of Virginia, Charlottesville, Virginia 22908.
Scripps Research Institute · USUniversity of Virginia · US

Funding

Regulatory Role of Growth Hormone Secretagogue ReceptorR01AG019230 · NIA · SCRIPPS RESEARCH INSTITUTE, THE · PI SMITH, ROY G · 2001 to 2012
$3.6M
Ghrelin Regulation: Implications for Understanding ObesityR01DK076037 · NIDDK · UNIVERSITY OF VIRGINIA · PI THORNER, MICHAEL O · 2008 to 2012
$2.7M
Systemic Factors that Maintain a Young Liver PhenotypeR01AG029740 · NIA · SCRIPPS RESEARCH INSTITUTE, THE · PI SMITH, ROY G · 2008 to 2012
$1.9M
NIA NIH HHS R01 AG019230NIA NIH HHS R01 AG029740NIA NIH HHS R01AG19230NIA NIH HHS R01AG29740NIDDK NIH HHS R01 DK076037NIDDK NIH HHS R01DK076037
6 · The paper itself

Abstract

Aging is associated with attenuated ghrelin signaling. During aging, chronic caloric restriction (CR) produces health benefits accompanied by enhanced ghrelin production. Ghrelin receptor (GH secretagogue receptor 1a) agonists administered to aging rodents and humans restore the young adult phenotype; therefore, we tested the hypothesis that the metabolic benefits of CR are mediated by endogenous ghrelin. Three month-old male mice lacking ghrelin (Ghrelin-/-) or ghrelin receptor (Ghsr-/-), and their wild-type (WT) littermates were randomly assigned to 2 groups: ad libitum (AL) fed and CR, where 40% food restriction was introduced gradually to allow Ghrelin-/- and Ghsr-/- mice to metabolically adapt and avoid severe hypoglycemia. Twelve months later, plasma ghrelin, metabolic parameters, ambulatory activity, hypothalamic and liver gene expression, as well as body composition were measured. CR increased plasma ghrelin and des-acyl ghrelin concentrations in WT and Ghsr-/- mice. CR of WT, Ghsr-/-, and Ghrelin-/- mice markedly improved metabolic flexibility, enhanced ambulatory activity, and reduced adiposity. Inactivation of Ghrelin or Ghsr had no effect on AL food intake or food anticipatory behavior. In contrast to the widely held belief that endogenous ghrelin regulates food intake, CR increased expression of hypothalamic Agrp and Npy, with reduced expression of Pomc across genotypes. In the AL context, ablation of ghrelin signaling markedly inhibited liver steatosis, which correlated with reduced Pparγ expression and enhanced Irs2 expression. Although CR and administration of GH secretagogue receptor 1a agonists both benefit the aging phenotype, we conclude the benefits of chronic CR are a consequence of enhanced metabolic flexibility independent of endogenous ghrelin or des-acyl ghrelin signaling.

Indexed as

Caloric RestrictionAge FactorsAgouti-Related ProteinAnimalsBody CompositionEatingEnergy MetabolismGene ExpressionGhrelinHumansHypothalamusLiverMaleMice, Inbred C57BLMice, KnockoutNeuronsAgouti-Related ProteinAgrp protein, mouseGhrelinNeuropeptide YReceptors, Ghrelin

Identifiers

PMID26812158
PMCPMC4816730
OpenAlexW2256722144

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.