ArticlePloS one2016
Nontuberculous Mycobacterial Disease in Children - Epidemiology, Diagnosis & Management at a Tertiary Center.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 93 citations in OpenAlex.
- Article
- Seven decades of nontuberculous mycobacteria in Denmark: shifts in species distribution and clinical relevance.Journal of clinical microbiology · 2026Article
- Can Oral Swabs Be Used to Diagnose Nontuberculous Mycobacterial Cervicofacial Lymphadenitis?The Laryngoscope · 2025Article
- Subacute Mastoiditis Without Verified Nontuberculous Mycobacteria-Still a Clinical Challenge.Laryngoscope investigative otolaryngology · 2025Article
- Relationship between age, sex, geography and incidence of nontuberculous mycobacteria in Denmark from 1991 to 2022.ERJ open research · 2025Article
- A 28-Year Multicenter Cohort Study of Nontuberculous Mycobacterial Lymphadenitis in Children, Spain.Emerging infectious diseases · 2025Article
- Disseminated Macrolide-Resistant Mycobacterium intracellulare Infection in a Child with Autoimmune Lymphoproliferative Disorder: A Case Report and Literature Review.The American journal of tropical medicine and hygiene · 2024Review
- Nontuberculous mycobacterial disease in children: A systematic review and meta-analysis.Heliyon · 2024Article
- Late recurrence in surgically managed pediatric atypical mycobacterial lymphadenitis: A case report and review of the literature.World journal of otorhinolaryngology - head and neck surgery · 2023Review
- Management of nontuberculous mycobacteria in lung transplant cases: an international Delphi study.ERJ open research · 2023Article
- Management of Infectious Lymphadenitis in Children.Children (Basel, Switzerland) · 2021Review
- Diagnosis of nontuberculous mycobacterial lymphadenitis: the role of fine-needle aspiration.European journal of pediatrics · 2021Article
- Pulmonary Nontuberculous Mycobacterial Infection in Infants: A Systematic Review.Pediatric health, medicine and therapeutics · 2021Review
- Osteomyelitis Due to Mycobacterium goodii in an Adolescent, United States.Emerging infectious diseases · 2020Article
- Non-Tuberculous Mycobacterial Diseases in Children.Pathogens (Basel, Switzerland) · 2020Review
- Characteristics of clinical extrapulmonary nontuberculous mycobacteria isolates in Minnesota, 2013-2017.Minnesota medicine · 2020Article
- Current and future management of non-tuberculous mycobacterial pulmonary disease (NTM-PD) in the UK.BMJ open respiratory research · 2020Review
- Risk Factors for Complicated Lymphadenitis Caused by Nontuberculous Mycobacteria in Children.Emerging infectious diseases · 2020Article
- Nontuberculous mycobacterial infections in a Brazilian pediatric population: a seven-year survey.Pathogens and global health · 2020Article
- Emerging and re-emerging infectious disease in otorhinolaryngology.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2018Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere are limited data on the epidemiology, diagnosis and optimal management of nontuberculous mycobacterial (NTM) disease in children.
methodsRetrospective cohort study of NTM cases over a 10-year-period at a tertiary referral hospital in Australia.
resultsA total of 140 children with NTM disease, including 107 with lymphadenitis and 25 with skin and soft tissue infections (SSTIs), were identified. The estimated incidence of NTM disease was 0.6-1.6 cases / 100,000 children / year; no increasing trend was observed over the study period. Temporal analyses revealed a seasonal incidence cycle around 12 months, with peaks in late winter/spring and troughs in autumn. Mycobacterium-avium-complex accounted for most cases (77.8%), followed by Mycobacterium ulcerans (14.4%) and Mycobacterium marinum (3.3%). Polymerase chain reaction testing had higher sensitivity than culture and microscopy for acid-fast bacilli (92.0%, 67.2% and 35.7%, respectively). The majority of lymphadenitis cases underwent surgical excision (97.2%); multiple recurrences in this group were less common in cases treated with clarithromycin and rifampicin compared with clarithromycin alone or no anti-mycobacterial drugs (0% versus 7.1%; OR:0.73). SSTI recurrences were also less common in cases treated with two anti-mycobacterial drugs compared with one or none (10.5% versus 33.3%; OR:0.23).
conclusionsThere was seasonal variation in the incidence of NTM disease, analogous to recently published observations in tuberculosis, which have been linked to seasonal variation in vitamin D. Our finding that anti-mycobacterial combination therapy was associated with a reduced risk of recurrences in patients with NTM lymphadenitis or SSTI requires further confirmation in prospective trials.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.