ArticlePloS one2016
Deciphering Parameter Sensitivity in the BvgAS Signal Transduction.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- A population of bang-bang switches of defective interfering particles makes within-host dynamics of dengue virus controllable.PLoS computational biology · 2019Article
- In silico modeling of phosphorylation dependent and independent c-Myc degradation.BMC bioinformatics · 2019Article
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Authors and funding
4 authors.
Funding
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Abstract
To understand the switching of different phenotypic phases of Bordetella pertussis, we propose an optimized mathematical framework for signal transduction through BvgAS two-component system. The response of the network output to the sensory input has been demonstrated in steady state. An analysis in terms of local sensitivity amplification characterizes the nature of the molecular switch. The sensitivity analysis of the model parameters within the framework of various correlation coefficients helps to decipher the contribution of the modular structure in signal propagation. Once classified, the model parameters are tuned to generate the behavior of some novel strains using simulated annealing, a stochastic optimization technique.
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Registered trials
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