ArticleBrain, behavior, and immunity2016
Euflammation attenuates peripheral inflammation-induced neuroinflammation and mitigates immune-to-brain signaling.
Article in Brain, behavior, and immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Hippocampal neuroinflammation and altered peripheral neurobiological protein profile in experimental arthritis and systemic juvenile idiopathic arthritis.EBioMedicine · 2026Article
- Neuroinflammation strokes the brain: A double-edged sword in ischemic stroke.Neural regeneration research · 2026Article
- Redox Regulation of the NLRP3 Inflammasome and its Implications for Immunization-related Neuroinflammation.Molecular neurobiology · 2026Review
- Pretreatment with the psychedelic DOI mitigates LPS-induced hippocampal inflammation and behavioral impairments in mice.BMC neuroscience · 2026Article
- Microalgae-based bacteria for oral treatment of ASD through enhanced intestinal colonization and homeostasis.Theranostics · 2025Article
- The Modulation of Neuroimmune Responses in Peripheral Inflammation.Journal of inflammation research · 2025Review
- A transient blood IL-17 increase triggers neuroinflammation in cerebellum and motor incoordination in hyperammonemic rats.Journal of neuroinflammation · 2024Article
- The role of microglia in 67NR mammary tumor-induced suppression of brain responses to immune challenges in female mice.Journal of neurochemistry · 2024Article
- Update on the mechanism of microglia involvement in post-stroke cognitive impairment.Frontiers in aging neuroscience · 2024Review
- Inflammatory processes in the prefrontal cortex induced by systemic immune challenge: Focusing on neurons.Brain, behavior, & immunity - health · 2023Article
- Liposaccharide-induced sustained mild inflammation fragments social behavior and alters basolateral amygdala activity.Psychopharmacology · 2023Article
- Leukotrienes vs. Montelukast-Activity, Metabolism, and Toxicity Hints for Repurposing.Pharmaceuticals (Basel, Switzerland) · 2022Review
- The Immunopathogenesis of Alzheimer's Disease Is Related to the Composition of Gut Microbiota.Nutrients · 2021Review
- The Perfect Cytokine Storm: How Peripheral Immune Challenges Impact Brain Plasticity & Memory Function in Aging.Brain plasticity (Amsterdam, Netherlands) · 2021Review
- Chemical Analysis of the Ingredients of 20% Aqueous Ethanol Extract ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Multiple Anesthesia/Surgery Cannot Impair Reference Memory in Adult Mice.Mediators of inflammation · 2020Article
- Mammary tumor and mastectomy synergistically promote neuroinflammation in a breast cancer survivor model.Brain research · 2019Article
- Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities.Immunity · 2019Article
- Tumor resection ameliorates tumor-induced suppression of neuroinflammatory and behavioral responses to an immune challenge in a cancer survivor model.Scientific reports · 2019Article
- Remodeling of Retinal Architecture in Diabetic Retinopathy: Disruption of Ocular Physiology and Visual Functions by Inflammatory Gene Products and Pyroptosis.Frontiers in physiology · 2018Review
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Authors and funding
13 authors.
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Abstract
Peripheral inflammation can trigger a number of neuroinflammatory events in the CNS, such as activation of microglia and increases of proinflammatory cytokines. We have previously identified an interesting phenomenon, termed "euflammation", which can be induced by repeated subthreshold infectious challenges. Euflammation causes innate immune alterations without overt neuroimmune activation. In the current study, we examined the protective effect of euflammation against peripheral inflammation-induced neuroinflammation and the underlying mechanisms. When Escherichia coli or lipopolysaccharide (LPS) was injected inside or outside the euflammation induction locus (EIL), sickness behavior, global microglial activation, proinflammatory cytokine production in the brain, expression of endothelial cyclooxygenase II and induction of c-fos expression in the paraventricular nucleus of the hypothalamus were all attenuated in the euflammatory mice compared with those in the control unprimed mice. Euflammation also modulated innate immunity outside the EIL by upregulating receptors for pathogen-associated molecular patterns in spleen cells. In addition, euflammation attenuated CNS activation in response to an intra-airpouch (outside the EIL) injection of LPS without suppressing the cytokine expression in the airpouch. Collectively, our study demonstrates that signaling of peripheral inflammation to the CNS is modulated dynamically by peripheral inflammatory kinetics. Specifically, euflammation can offer effective protection against both bacterial infection and endotoxin induced neuroinflammation.
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