ArticleJournal of the American Chemical Society2016
A Miniature Protein Stabilized by a Cation-π Interaction Network.
Article in Journal of the American Chemical Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Unveiling the alkyne-π interaction using metal-organic cage compounds.Communications chemistry · 2025Article
- Supra-biological performance of immobilized enzymes enabled by chaperone-like specific non-covalent interactions.Nature communications · 2024Article
- AQcalc: A web server that identifies weak molecular interactions in protein structures.Protein science : a publication of the Protein Society · 2023Article
- Design and Engineering of Miniproteins.ACS bio & med chem Au · 2022Review
- Chiral, sequence-definable foldamer-derived macrocycles.Chemical science · 2021Article
- The First Cytoplasmic Loop in the Core Structure of the ABCC1 (Multidrug Resistance Protein 1; MRP1) Transporter Contains Multiple Amino Acids Essential for Its Expression.International journal of molecular sciences · 2021Article
- Biomolecular Modeling and Simulation: A Prospering Multidisciplinary Field.Annual review of biophysics · 2021Article
- Yeast- and antibody-based tools for studying tryptophan C-mannosylation.Nature chemical biology · 2021Article
- Article
- Spectroscopic and Theoretical Studies of Hg(II) Complexation with Some Dicysteinyl Tetrapeptides.Bioinorganic chemistry and applications · 2021Article
- Conformation control through concurrent N-H⋯S and N-H⋯O[double bond, length as m-dash]C hydrogen bonding and hyperconjugation effects.Chemical science · 2020Article
- Cation-π binding ability of BN indole.Chemical communications (Cambridge, England) · 2020Article
- Secondary Forces in Protein Folding.ACS chemical biology · 2019Review
- Amorphous AgiScience · 2019Article
- A cation-π interaction in a transmembrane helix of vacuolar ATPase retains the proton-transporting arginine in a hydrophobic environment.The Journal of biological chemistry · 2018Article
- Protein stabilization by tuning the steric restraint at the reverse turn.Chemical science · 2018Article
- Article
- Designing cooperatively folded abiotic uni- and multimolecular helix bundles.Nature chemistry · 2018Article
- Engineering protein stability with atomic precision in a monomeric miniprotein.Nature chemical biology · 2017Article
- Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin.Structure (London, England : 1993) · 2017Article
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Authors and funding
5 authors.
Funding
Abstract
The design of folded miniature proteins is predicated on establishing noncovalent interactions that direct the self-assembly of discrete thermostable tertiary structures. In this work, we describe how a network of cation-π interactions present in proteins containing "WSXWS motifs" can be emulated to stabilize the core of a miniature protein. This 19-residue protein sequence recapitulates a set of interdigitated arginine and tryptophan residues that stabilize a distinctive β-strand:loop:PPII-helix topology. Validation of the compact fold determined by NMR was carried out by mutagenesis of the cation-π network and by comparison to the corresponding disulfide-bridged structure. These results support the involvement of a coordinated set of cation-π interactions that stabilize the tertiary structure.
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