Evidence map›Paper›PMID 26812060›Full record

ReviewHLA2016

Innate lymphoid cells and the MHC.

M L Robinette, M Colonna

Abstract readReview
In one paragraph

Review in HLA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Animals have expanded the evolutionary legacy of unicellular ancestors in blood cells.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Parallel origins and functions of T cells and ILCs.Clinical and experimental immunology · 2023
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. T cells in severe childhood asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019
    Review
  13. NCREBioMedicine · 2019
    Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

M L RobinetteDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
M ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.

Funding

Mucosal Immune Defense Mechanisms of the Urinary BladderU01AI095542 · NIAID · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, HULTGREN, SCOTT J. · 2011 to 2020
$9.8M
THE ROLE OF NK-22 CELLS IN ANTI-HIV-1 MUCOSAL IMMUNITYR01DE021255 · NIDCR · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2010 to 2014
$1.9M
CONTROLLING NK CELL ANTI-CANCER ACTIVITY: THE ROLE OF NUTRIENTS AND SUPPLEMENTSR21CA167192 · NCI · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2013 to 2014
$358k
NCI NIH HHS R21CA16719NCI NIH HHS R21 CA167192NIAID NIH HHS 1U01AI095542NIAID NIH HHS U01 AI095542NIDCR NIH HHS R01 DE021255NIDCR NIH HHS R01DE021255
6 · The paper itself

Abstract

Innate lymphoid cells (ILCs) are a new class of immune cells that include natural killer (NK) cells and appear to be the innate counterparts to CD4(+) helper T cells and CD8(+) cytotoxic T cells based on developmental and functional similarities. Like T cells, both NK cells and other ILCs also show connections to the major histocompatibility complex (MHC). In human and mouse, NK cells recognize and respond to classical and nonclassical MHC I molecules as well as structural homologues, whereas mouse ILCs have recently been shown to express MHC II. We describe the history of MHC I recognition by NK cells and discuss emerging roles for MHC II expression by ILC subsets, making comparisons between both mouse and human when possible.

Indexed as

Immunity, InnateMajor Histocompatibility ComplexAnimalsAntigens, CDCytokinesGene ExpressionHumansKiller Cells, NaturalMiceReceptors, NK Cell Lectin-LikeSpecies SpecificityT-Lymphocytes, CytotoxicT-Lymphocytes, Helper-InducerAntigens, CDCytokinesReceptors, NK Cell Lectin-Likecytokineshumanhuman leukocyte antigeninnateInnate lymphoid cellsMHCmouse

Identifiers

PMID26812060
PMCPMC5658205

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.