ArticlePloS one2016
Epidemiology of Birth Defects Based on a Birth Defect Surveillance System from 2005 to 2014 in Hunan Province, China.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Congenital anomalies and risk factors in Africa: a systematic review and meta-analysis.BMJ paediatrics open · 2023Pooled it
- Age-specific global epidemiology of hydrocephalus: Systematic review, metanalysis and global birth surveillance.PloS one · 2018Pooled it
- Down syndrome burden in China and globally: a comparative analysis of 1990-2021 trends and future projections based on GBD 2021 database.Frontiers in public health · 2025Article
- Evidence of the correlation between air pollution and different types of birth defects: based on a distribution-lag non-linear model.Frontiers in public health · 2025Article
- Temporal trends in the prevalence of major birth defects in China: a nationwide population-based study from 2007 to 2021.World journal of pediatrics : WJP · 2024Article
- What are they considering when they face a fetus with birth defects? A qualitative study on ethical attitudes of health professionals in China.Global health research and policy · 2024Article
- Multivariate logistic regression analysis of risk factors for birth defects: a study from population-based surveillance data.BMC public health · 2024Article
- Epidemiology of congenital polydactyly and syndactyly in Hunan Province, China.BMC pregnancy and childbirth · 2024Article
- Prevalence, characteristics and risk factors of birth defects in central China livebirths, 2015-2022.Frontiers in public health · 2024Article
- Update from a cohort study for birth defects in Hunan Province, China, 2010-2020.Scientific reports · 2023Article
- The effect of China's many-child policy on the number of births and the prevalence of serious teratogenic and disabling defects in Hunan Province.BMC public health · 2023Observational
- Analyzing the Trends and Causes of Birth Defects - Jinan City, Shandong Province, China, 2005-2022.China CDC weekly · 2023Article
- Ambient air pollutants in the first trimester of pregnancy and birth defects: an observational study.BMJ open · 2023Observational
- The burden of congenital birth defects between 1990 and 2019 in China: an observational study.Frontiers in pediatrics · 2023Article
- Noncardiac anomalies in children with congenital heart disease.Frontiers in cardiovascular medicine · 2023Article
- Epidemiology of birth defects in a national hospital-based birth defect surveillance spot in Southern Jiangsu, China, 2014-2018.Frontiers in medicine · 2023Article
- Epidemiological and Spatiotemporal Descriptive Analysis of Patients with Nonsyndromic Cleft Lip and/or Palate: A 12-Year Retrospective Study in Southern Iran.BioMed research international · 2023Article
- Reducing Birth Defects by Decreasing the Prevalence of Maternal Chronic Diseases-Evaluated by Linked National Registration Dataset.Children (Basel, Switzerland) · 2022Article
- [Pregnancy management in patients with hepatolenticular degeneration].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022Review
- Mobile Phone App Use Among Pregnant Women in China and Associations Between App Use and Perinatal Outcomes: Retrospective Study.JMIR formative research · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo describe the epidemiology of birth defects (BDs) in perinatal infants in Hunan Province, China, between 2005 and 2014.
methodsThe BD surveillance data of perinatal infants (for stillbirth, dead fetus or live birth between 28 weeks of gestation and 7 days after birth) were collected from 52 registered hospitals of Hunan between 2005 and 2014. The prevalence rates of BDs with 95% confidence interval (CI) and crude odds ratio (ORs) were calculated to examine the associations of infant gender, maternal age, and region (urban vs rural) with BDs.
resultsFrom 2005 to 2014, there were a total of 925413 perinatal infants of which 17753 had BDs, with the average prevalence of 191.84 per 10000 PIs (perinatal infants), showing a significant uptrend. The risks of BDs are higher in urban areas versus rural areas (OR = 1.20), in male infants versus female infants (OR = 1.19), and in mothers above age 35 versus those below age 35 (OR = 1.24). The main five types of BDs are Congenital heart defects (CHD), Other malformation of external ear (OMEE), Polydactyly, Congenital malformation of kidney (CMK), and Congenital talipes equinovarus (CTE). From 2005 to 2014, the prevalence rates (per 10000 PIs) of CHD and CMK increased significantly from 22.56 to 74 (OR = 3.29, 95%CI: 2.65-4.11) and from 7.61 to 14.62 (OR = 1.92, 95%CI:1.30-2.84), respectively; the prevalence rates of congenital hydrocephalus and neural tube defects (NTDs) decreased significantly from 11.8 to 5.29 (OR = 0.45, 95%CI: 0.31-0.65) and from 7.87 to 1.74 (OR = 0.22, 95%CI: 0.13-0.38), respectively.
conclusionsThe prevalence rates of specific BDs in perinatal infants in Hunan have changed in the last decade. Urban pregnant women, male perinatal infants, and mothers above age 35 present different prevalence rates of BDs. Wider use of new diagnosis technology, improving the ability of monitoring, strengthening the publicity and education are important to reduce the prevalence of BDs.
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