Evidence map›Paper›PMID 26811973›Full record

ArticleNMR in biomedicine2016

Capturing fast relaxing spins with SWIFT adiabatic rotating frame spin-lattice relaxation (T1ρ) mapping.

J Zhang, M J Nissi, D Idiyatullin, S Michaeli, M Garwood, J Ellermann

Abstract read
In one paragraph

Article in NMR in biomedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. RJournal of magnetic resonance (San Diego, Calif. : 1997) · 2026
    Article
  3. Review
  4. European heart journal. Imaging methods and practice · 2025
    Article
  5. Article
  6. Alternating Look-Locker for quantitative TMagnetic resonance in medicine · 2024
    Article
  7. Article
  8. Article
  9. Magic angle effect on adiabatic TNMR in biomedicine · 2020
    Article
  10. Review
  11. Article
  12. 3D adiabatic TMagnetic resonance in medicine · 2018
    Article
  13. Biexponential TNMR in biomedicine · 2017
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

J ZhangCenter for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, USA.
M J NissiCenter for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, USA.
D IdiyatullinCenter for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, USA.
S MichaeliCenter for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, USA.
M GarwoodCenter for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, USA.
J EllermannCenter for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, USA.

Funding

NMR Imaging and SpectroscopyP41EB015894 · NIBIB · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2017
$8.4M
NIBIB NIH HHS P41 EB015894
6 · The paper itself

Abstract

Rotating frame spin-lattice relaxation, with the characteristic time constant T1ρ, provides a means to access motion-restricted (slow) spin dynamics in MRI. As a result of their restricted motion, these spins are sometimes characterized by a short transverse relaxation time constant T2 and thus can be difficult to detect directly with conventional image acquisition techniques. Here, we introduce an approach for three-dimensional adiabatic T1ρ mapping based on a magnetization-prepared sweep imaging with Fourier transformation (MP-SWIFT) sequence, which captures signal from almost all water spin populations, including the extremely fast relaxing pool. A semi-analytical procedure for T1ρ mapping is described. Experiments on phantoms and musculoskeletal tissue specimens (tendon, articular and epiphyseal cartilages) were performed at 9.4 T for both the MP-SWIFT and fast spin echo (FSE) read outs. In the phantom with liquids having fast molecular tumbling and a single-valued T1ρ time constant, the measured T1ρ values obtained with MP-SWIFT and FSE were similar. Conversely, in normal musculoskeletal tissues, T1ρ values measured with MP-SWIFT were much shorter than the values obtained with FSE. Studies of biological tissue specimens demonstrated that T1ρ-weighted SWIFT provides higher contrast between normal and diseased tissues relative to conventional acquisitions. Adiabatic T1ρ mapping with SWIFT readout captures contributions from the otherwise undetected fast relaxing spins, allowing more informative T1ρ measurements of normal and diseased states.

Indexed as

Fourier AnalysisRotationSpin LabelsAnimalsCattleComputer SimulationMagnetic Resonance ImagingSus scrofaSpin Labelsbound watermusculoskeletalrelaxometryrotating frame relaxationSWIFTultrashort T2

Identifiers

PMID26811973
PMCPMC4805510

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.