SynthesisPloS one2016
Early Life Origins of Lung Ageing: Early Life Exposures and Lung Function Decline in Adulthood in Two European Cohorts Aged 28-73 Years.
Synthesis in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Socioeconomic circumstances and respiratory function from childhood to early adulthood: a systematic review and meta-analysis.BMJ open · 2019Pooled it
- Associations of current and life-course smoking and indoor environmental exposures with lung function level in early adulthood.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Childhood Environmental Exposures and Adult Disease.Pediatric pulmonology · 2026Review
- Perinatal exposures and adolescence overweight: The role of shared maternal-offspring pathways.Atherosclerosis · 2024Article
- The association of maternal smoking around birth with chronic respiratory diseases in adult offspring: A Mendelian randomization study.Tobacco induced diseases · 2024Article
- Early life exposures contributing to accelerated lung function decline in adulthood - a follow-up study of 11,000 adults from the general population.EClinicalMedicine · 2023Article
- Going Down, Dooby Doo Down, Down: Identifying Rapid Spirometry Decline.American journal of respiratory and critical care medicine · 2023Article
- Prenatal Ambient Air Pollutant Mixture Exposure and Early School-age Lung Function.Environmental epidemiology (Philadelphia, Pa.) · 2023Article
- Too Little, Too Late: Adult Lung Disease Cannot Be Prevented by Interventions in Adult Life.American journal of respiratory and critical care medicine · 2023Article
- Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings.PLoS genetics · 2023Article
- Asthma and Tobacco Smoking.Journal of personalized medicine · 2022Review
- Socioeconomic circumstances and lung function growth from early adolescence to early adulthood.Pediatric research · 2021Article
- Growing, Growing, Gone: The Double Whammy of Early Deprivation and Impaired Evolution of Lung Function.American journal of respiratory and critical care medicine · 2021Article
- Unfriendly Fire: How the Tobacco Industry is Destroying the Future of Our Children.Acta medica Lituanic · 2021Review
- E-Cigarettes as a Growing Threat for Children and Adolescents: Position Statement From the European Academy of Paediatrics.Frontiers in pediatrics · 2021Article
- Associations of Preconception Exposure to Air Pollution and Greenness with Offspring Asthma and Hay Fever.International journal of environmental research and public health · 2020Article
- Validation of the global lung initiative 2012 multi-ethnic spirometric reference equations in healthy urban Zimbabwean 7-13 year-old school children: a cross-sectional observational study.BMC pulmonary medicine · 2020Observational
- The scars of the past? Childhood health and health differentials in later life.SSM - population health · 2019Article
- Epigenetic impacts of maternal tobacco and e-vapour exposure on the offspring lung.Clinical epigenetics · 2019Review
- Independent and combined associations of maternal and own smoking with adult lung function and COPD.International journal of epidemiology · 2018Article
Corrections and comments
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesEarly life environment is essential for lung growth and maximally attained lung function. Whether early life exposures impact on lung function decline in adulthood, an indicator of lung ageing, has scarcely been studied.
methodsSpirometry data from two time points (follow-up time 9-11 years) and information on early life exposures, health and life-style were available from 12862 persons aged 28-73 years participating in the European population-based cohorts SAPALDIA (n = 5705) and ECRHS (n = 7157). The associations of early life exposures with lung function (FEV1) decline were analysed using mixed-effects linear regression.
resultsEarly life exposures were significantly associated with FEV1 decline, with estimates almost as large as personal smoking. FEV1 declined more rapidly among subjects born during the winter season (adjusted difference in FEV1/year of follow-up [95%CI] -2.04ml [-3.29;-0.80]), of older mothers, (-1.82 ml [-3.14;-0.49]) of smoking mothers (-1.82ml [-3.30;-0.34] or with younger siblings (-2.61ml [-3.85;-1.38]). Less rapid FEV1-decline was found in subjects who had attended daycare (3.98ml [2.78;5.18]), and indicated in subjects with pets in childhood (0.97ml [-0.16;2.09]). High maternal age and maternal smoking appeared to potentiate effects of personal smoking. The effects were independent of asthma at any age.
conclusionEarly life factors predicted lung function decline decades later, suggesting that some mechanisms related lung ageing may be established early in life. Early life programming of susceptibility to adult insults could be a possible pathway that should be explored further.
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