ArticleIranian journal of parasitology
Encephalitozoon cuniculi infection among immunocompromised and immunocompetent humans in Egypt.
Article in Iranian journal of parasitology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Clinical Molecular Investigation of Encephalitozoon cuniculi in Pet Rabbits: Early Detection of Potential Risk for Animal and Human Infection.Veterinary medicine and science · 2026Article
- Molecular Detection ofPathogens (Basel, Switzerland) · 2025Article
- Wildlife as Reservoirs of Encephalitozoon Cuniculi and Encephalitozoon Hellem and Molecular Genotyping of Encephalitozoon spp. in Small Mammals in the Czech Republic.Acta parasitologica · 2024Article
- Molecular Detection ofInternational journal of molecular sciences · 2023Article
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- A multidisciplinary review about Encephalitozoon cuniculi in a One Health perspective.Parasitology research · 2022Review
- Chronic Infections in Mammals Due to Microsporidia.Experientia supplementum (2012) · 2022Article
- Zoonotic Risk ofInternational journal of environmental research and public health · 2021Review
- Encephalitozoon cuniculi Genotype III Evinces a Resistance to Albendazole Treatment in both Immunodeficient and Immunocompetent Mice.Antimicrobial agents and chemotherapy · 2020Article
- Innate and Adaptive Immune Responses Against Microsporidia Infection in Mammals.Frontiers in microbiology · 2020Review
- Increased phagocytosis and growth inhibition of Encephalitozoon cuniculi by LPS-activated J774A.1 murine macrophages.Parasitology research · 2019Article
- Seroprevalence of Toxoplasma gondii and Encephalitozoon cuniculi among domestic rabbits in central China.Parasite (Paris, France) · 2018Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEncephalitozoon cuniculi infects a wide range of homoeothermic animals, including man. Complications due to this microsporidian have been reported only in immunocompromised patients. Reports on E. cuniculi in immunocompetent humans are lacking, most probably, because it is not linked to any clinical manifestations in such hosts. The present work was carried out with the aim of studying, for the first time in Egypt, the prevalence of E. cuniculi infection of urinary tract among non-HIV immunocompromised patients and immunocompetent individuals. It tested also the influence of some factors on the risk of infection.
methodsBlood and urine samples were collected from 88 persons (44 non-HIV immunocompromised patients and 44 subjects as immunocompetent control group). IFAT serological assay and Weber's green modified trichrome stain (MTS) urine smears were carried out. Molecular study by PCR was also performed to detect DNA of E. cuniculi in urine samples. A full history sheet was fulfilled for each subject to test the suspected risk factors.
resultsThe IFAT examination confirmed the presence of antibodies against E. cuniculi in 44.3% of the human subjects. The seroprevalence of E. cuniculi was significantly higher in the immunocompromised patients compared with the immunocompetent individuals (77.3% versus 11.4%). Compared with IFAT (the gold standard), the sensitivity and specificity of Weber's green MTS smears were 69.23% and 89.80%. By using PCR, no positive cases were detected among human subjects.
conclusionA high prevalence of E. cuniculi infection in the studied individuals was noted. Although infection was found in some immunocompetent individuals, the immune status of the host remains the corner stone for occurrence of the infection.
Indexed as
Identifiers
26811722PMC4724832W2206054137What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.