Evidence map›Paper›PMID 26811665›Full record

ReviewWorld journal of gastroenterology2016

Recent advances in photodynamic diagnosis of gastric cancer using 5-aminolevulinic acid.

Noriaki Koizumi, Yoshinori Harada, Takeo Minamikawa, Hideo Tanaka, Eigo Otsuji, Tetsuro Takamatsu

Open access · hybridAbstract readReview
In one paragraph

Review in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Noriaki KoizumiNoriaki Koizumi, Yoshinori Harada, Takeo Minamikawa, Hideo Tanaka, Tetsuro Takamatsu, Department of Pathology and Cell Regulation, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 6028566, Japan.
Yoshinori HaradaNoriaki Koizumi, Yoshinori Harada, Takeo Minamikawa, Hideo Tanaka, Tetsuro Takamatsu, Department of Pathology and Cell Regulation, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 6028566, Japan.
Takeo MinamikawaNoriaki Koizumi, Yoshinori Harada, Takeo Minamikawa, Hideo Tanaka, Tetsuro Takamatsu, Department of Pathology and Cell Regulation, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 6028566, Japan.
Hideo TanakaNoriaki Koizumi, Yoshinori Harada, Takeo Minamikawa, Hideo Tanaka, Tetsuro Takamatsu, Department of Pathology and Cell Regulation, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 6028566, Japan.
Eigo OtsujiNoriaki Koizumi, Yoshinori Harada, Takeo Minamikawa, Hideo Tanaka, Tetsuro Takamatsu, Department of Pathology and Cell Regulation, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 6028566, Japan.
Tetsuro TakamatsuNoriaki Koizumi, Yoshinori Harada, Takeo Minamikawa, Hideo Tanaka, Tetsuro Takamatsu, Department of Pathology and Cell Regulation, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 6028566, Japan.
Nishijin Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photodynamic diagnosis based on 5-aminolevulinic acid-induced protoporphyrin IX has been clinically applied in many fields based upon its evidenced efficacy and adequate safety. In order to establish a personalized medicine approach for treating gastric cancer patients, rapid intraoperative detection of malignant lesions has become important. Feasibility of photodynamic diagnosis using 5-aminolevulinic acid for gastric cancer patients has been investigated, especially for the detection of peritoneal dissemination and lymph node metastasis. This method enables intraoperative real-time fluorescence detection of peritoneal dissemination, exhibiting higher sensitivity than white light observation without histopathological examination. The method also enables detection of metastatic foci within excised lymph nodes, exhibiting a diagnostic accuracy comparable to that of a current molecular diagnostics technique. Although several complicating issues still need to be resolved, such as the effect of tissue autofluorescence and the insufficient depth penetration of excitation light, this simple and rapid method has the potential to become a useful diagnostic tool for gastric cancer, as well as urinary bladder cancer and glioma.

Indexed as

Molecular Diagnostic TechniquesAminolevulinic AcidAnimalsBiomarkers, TumorHumansIntraoperative CareLuminescent MeasurementsLymphatic MetastasisPeritoneal NeoplasmsPredictive Value of TestsProtoporphyrinsReproducibility of ResultsStomach NeoplasmsAminolevulinic AcidBiomarkers, Tumorprotoporphyrin IXProtoporphyrins5-aminolevulinic acidGastric cancerLymph node metastasisPeritoneal disseminationPersonalized medicinePhotodynamic diagnosisProtoporphyrin IX

Identifiers

PMID26811665
PMCPMC4716038
OpenAlexW2255359708

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.