Evidence map›Paper›PMID 26811638›Full record

ReviewWorld journal of gastroenterology2016

Protective links between vitamin D, inflammatory bowel disease and colon cancer.

Stacey Meeker, Audrey Seamons, Lillian Maggio-Price, Jisun Paik

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06551688 (Influence of Preoperative Vitamin D Level on Postoperative Pain in Breast Cancer Surgery Patients), which is not on this map. Cited by 65 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 1 pooled it
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06551688 completednot on this mapstarted 2024, after this paper: background citation

Influence of Preoperative Vitamin D Level on Postoperative Pain in Breast Cancer Surgery Patients: A Prospective Observational Study

TypeobservationalSponsorFayoum UniversityRan2024 to 2025Enrolled184ConditionsCancer Breast, Hypovitaminosis DArmsSerum 25(OH)D level
3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 1 synthesis or guideline pooled it, 149 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  5. Review
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  10. Observational
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  18. Role of dietary nutrients and metabolism in colorectal cancer.Asia Pacific journal of clinical nutrition · 2024
    Review
  19. Patterns of vitamin D testing and supplementation for children with inflammatory bowel disease in Australasia.JGH open : an open access journal of gastroenterology and hepatology · 2024
    Article
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Stacey MeekerStacey Meeker, Audrey Seamons, Lillian Maggio-Price, Jisun Paik, Department of Comparative Medicine, University of Washington, Seattle, WA 98195, United States.
Audrey SeamonsStacey Meeker, Audrey Seamons, Lillian Maggio-Price, Jisun Paik, Department of Comparative Medicine, University of Washington, Seattle, WA 98195, United States.
Lillian Maggio-PriceStacey Meeker, Audrey Seamons, Lillian Maggio-Price, Jisun Paik, Department of Comparative Medicine, University of Washington, Seattle, WA 98195, United States.
Jisun PaikStacey Meeker, Audrey Seamons, Lillian Maggio-Price, Jisun Paik, Department of Comparative Medicine, University of Washington, Seattle, WA 98195, United States.
University of Washington · US

Funding

UNIVERSITY OF WASHINGTON GI TRAINING GRANTT32DK007742 · NIDDK · UNIVERSITY OF WASHINGTON · PI GRADY, WILLIAM MALLORY · 1996 to 2022
$4.7M
Control of Colonic Inflammation and Tumor Growth by TGFBeta and Dietary Vitamin DR21CA149995 · NCI · UNIVERSITY OF WASHINGTON · PI MAGGIO-PRICE, LILLIAN · 2011 to 2012
$373k
NCI NIH HHS R21 CA149995NCI NIH HHS R21 CA149995-01A1NIDDK NIH HHS 5T32DK007742-17NIDDK NIH HHS T32 DK007742
6 · The paper itself

Abstract

Vitamin D deficiency has been associated with a wide range of diseases and multiple forms of cancer including breast, colon, and prostate cancers. Relatively recent work has demonstrated vitamin D to be critical in immune function and therefore important in inflammatory diseases such as inflammatory bowel disease (IBD). Because vitamin D deficiency or insufficiency is increasingly prevalent around the world, with an estimated 30%-50% of children and adults at risk for vitamin D deficiency worldwide, it could have a significant impact on IBD. Epidemiologic studies suggest that low serum vitamin D levels are a risk factor for IBD and colon cancer, and vitamin D supplementation is associated with decreased colitis disease activity and/or alleviated symptoms. Patients diagnosed with IBD have a higher incidence of colorectal cancer than the general population, which supports the notion that inflammation plays a key role in cancer development and underscores the importance of understanding how vitamin D influences inflammation and its cancer-promoting effects. In addition to human epidemiological data, studies utilizing mouse models of colitis have shown that vitamin D is beneficial in preventing or ameliorating inflammation and clinical disease. The precise role of vitamin D on colitis is unknown; however, vitamin D regulates immune cell trafficking and differentiation, gut barrier function and antimicrobial peptide synthesis, all of which may be protective from IBD and colon cancer. Here we focus on effects of vitamin D on inflammation and inflammation-associated colon cancer and discuss the potential use of vitamin D for protection and treatment of IBD and colon cancer.

Indexed as

Dietary SupplementsAnimalsBiomarkersColonic NeoplasmsGastrointestinal MicrobiomeHost-Pathogen InteractionsHumansInflammatory Bowel DiseasesNutritional StatusProtective FactorsRisk FactorsSignal TransductionVitamin DVitamin D DeficiencyBiomarkersVitamin DColitisColon cancerInflammation-associated colon cancerInflammatory bowel diseaseMouse modelsVitamin D

Identifiers

PMID26811638
PMCPMC4716046
OpenAlexW2401419008

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.