ArticleJournal of cytology
Comparative cytomorphometric analysis of oral mucosal cells in normal, tobacco users, oral leukoplakia and oral squamous cell carcinoma.
Article in Journal of cytology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Quantitative evidence-based thresholds for exfoliative cytology based early detection of dysplasia in oral potentially malignant disorders - a systematic review and meta-analysis.Evidence-based dentistry · 2026Pooled it
- Trimodal cytological integration of micronuclei assay, argyrophilic nucleolar organizer region staining, and cytomorphometry enhances diagnostic discrimination of canine gingival masses.Veterinary world · 2026Article
- Establishing reference values for normal tongue squamous cells: An investigation of atypical changes.CytoJournal · 2025Article
- Clinical and Histopathological Features of Primary Oral Cancers in Shiraz, Iran: A 7- Years Retrospective Study.Galen medical journal · 2024Article
- Comparative Analysis of Cytomorphology in Adolescent and Geriatric Patients: A Cross-Sectional Study.Cureus · 2023Article
- Cytomorphometric Analysis of Oral Buccal Mucosa of Dental Colleges' Students in Sulaimani City.Diagnostics (Basel, Switzerland) · 2023Article
- Assessing the Effect of Curcumin on the Oral Mucosal Cytomorphometry and Candidal Species Specificity in Tobacco Users: A Pilot Study.Healthcare (Basel, Switzerland) · 2022Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSquamous cell carcinoma (SCC) is the third most common cause of oral morbidity in India despite the numerous advances made in the treatment protocol.
aimTo compare the cytomorphometric changes of oral mucosal cells in normal subjects (Group I) with that of tobacco users without any lesion (Group II), tobacco users with oral leukoplakia (Group III), and tobacco users with oral SCC (Group IV) through a semi-automated image analysis system. MATERIALS AND
methodsOral mucosal cells collected from study subjects (n = 100) stained using rapid Papanicolaou stain. Photomicrograph of 50 nonoverlapping cells captured at 50× magnification with a digital image capture system. Cytomorphometric analysis of cells in the captured images was performed with Image-Pro image analysis software. Image analysis was performed to obtain cell diameter (CD), cytoplasmic area (CyA), nuclear diameter (ND), nuclear area (NA), and nuclear-to-cytoplasmic ratio. These values were statistically compared among the groups using one-way analysis of variance (ANOVA) and Mann-Whitney U test.
resultsThe ND, NA, and nuclear-to-cytoplasmic ratio values were found to be increased in the samples collected from leukoplakia and oral SCC. The CD and CyA decreased compared to the normal mucosa in oral SCC samples.
conclusionThe cytomorphometric changes observed in samples from oral SCC and oral leukoplakia were consistent with the current diagnostic features. Hence, the semi-automated cytomorphometric analysis of oral mucosal cells can be used as an objective adjunct diagnostic tool in the diagnosis of these lesions.
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