Evidence map›Paper›PMID 26811499›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2016

Is BOK required for apoptosis induced by endoplasmic reticulum stress?

Yuniel Fernandez-Marrero, Francine Ke, Nohemy Echeverry, Philippe Bouillet, Daniel Bachmann, Andreas Strasser, Thomas Kaufmann

Abstract readLetterComment
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Phosphorylation of Bok at Ser-8 blocks its ability to suppress IPCell communication and signaling : CCS · 2025
    Article
  3. Article
  4. Bok: real killer or bystander with non-apoptotic roles?Frontiers in cell and developmental biology · 2023
    Review
  5. Article
  6. Article
  7. BAX, BAK, and BOK: A Coming of Age for the BCL-2 Family Effector Proteins.Cold Spring Harbor perspectives in biology · 2020
    Review
  8. The Multifaceted Roles of the BCL-2 Family Member BOK.Frontiers in cell and developmental biology · 2020
    Review
  9. Bok regulates mitochondrial fusion and morphology.Cell death and differentiation · 2019
    Article
  10. Article
  11. Role of B-Cell Lymphoma 2 Ovarian Killer (BOK) in Acute Toxicity of Human Lung Epithelial Cells Caused by Cadmium Chloride.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. MOMP, cell suicide as a BCL-2 family business.Cell death and differentiation · 2018
    Review
  17. Non-apoptotic functions of BCL-2 family proteins.Cell death and differentiation · 2017
    Review
  18. Article
  19. Review
  20. ER Stress-Mediated Signaling: Action Potential and Ca(2+) as Key Players.International journal of molecular sciences · 2016
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Yuniel Fernandez-MarreroInstitute of Pharmacology, Medical Faculty, University of Bern, 3010 Bern, Switzerland;
Francine KeMolecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia.
Nohemy EcheverryInstitute of Pharmacology, Medical Faculty, University of Bern, 3010 Bern, Switzerland;
Philippe BouilletMolecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia.
Daniel BachmannInstitute of Pharmacology, Medical Faculty, University of Bern, 3010 Bern, Switzerland;
Andreas StrasserMolecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia.
Thomas KaufmannInstitute of Pharmacology, Medical Faculty, University of Bern, 3010 Bern, Switzerland; thomas.kaufmann@pki.unibe.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Oxidative StressAnimalsApoptosisEndoplasmic ReticulumProto-Oncogene Proteins c-bcl-2Proto-Oncogene Proteins c-bcl-2

Identifiers

PMID26811499
PMCPMC4747697

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.