ArticleProceedings of the National Academy of Sciences of the United States of America2016
Cryptochrome 2 mediates directional magnetoreception in cockroaches.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- Pooled it
- Genetic analysis of cryptochrome in insect magnetosensitivity.Frontiers in physiology · 2022Pooled it
- Trial
- From skylight cues to magnetic fields: the toolkit of insect long-distance navigation.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- Cryptochrome interaction networks across different tissues in Drosophila melanogaster.Biology direct · 2025Article
- A magnetotactic bacterium capable of magnetic sensing.iScience · 2025Article
- Coevolution ofiScience · 2025Article
- Article
- Magnetic sense-dependent probabilistic decision-making in humans.Frontiers in neuroscience · 2025Article
- Clock Gene Expression in Eel Retina and Hypothalamus: Response to Photoperiod and Moonlight.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2025Article
- Comparison of retinol binding protein 1 with cone specific G-protein as putative effector molecules in cryptochrome signalling.Scientific reports · 2024Article
- Circadian Rhythms of Locomotor Activity Mediated byInsects · 2023Article
- Photobehaviours guided by simple photoreceptor systems.Animal cognition · 2023Review
- A Review of the Current State of Magnetic Force Microscopy to Unravel the Magnetic Properties of Nanomaterials Applied in Biological Systems and Future Directions for Quantum Technologies.Nanomaterials (Basel, Switzerland) · 2023Review
- Insect magnetoreception: a Cry for mechanistic insights.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2023Review
- CrusTome: a transcriptome database resource for large-scale analyses across Crustacea.G3 (Bethesda, Md.) · 2023Article
- Probing Transcriptional Crosstalk betweenInternational journal of molecular sciences · 2023Article
- Electromagnetic fields disrupt the pollination service by honeybees.Science advances · 2023Article
- Cryptochrome and quantum biology: unraveling the mysteries of plant magnetoreception.Frontiers in plant science · 2023Review
- Cryptochromes in mammals: a magnetoreception misconception?Frontiers in physiology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to perceive geomagnetic fields (GMFs) represents a fascinating biological phenomenon. Studies on transgenic flies have provided evidence that photosensitive Cryptochromes (Cry) are involved in the response to magnetic fields (MFs). However, none of the studies tackled the problem of whether the Cry-dependent magnetosensitivity is coupled to the sole MF presence or to the direction of MF vector. In this study, we used gene silencing and a directional MF to show that mammalian-like Cry2 is necessary for a genuine directional response to periodic rotations of the GMF vector in two insect species. Longer wavelengths of light required higher photon fluxes for a detectable behavioral response, and a sharp detection border was present in the cyan/green spectral region. Both observations are consistent with involvement of the FADox, FAD(•-) and FADH(-) redox forms of flavin. The response was lost upon covering the eyes, demonstrating that the signal is perceived in the eye region. Immunohistochemical staining detected Cry2 in the hemispherical layer of laminal glia cells underneath the retina. Together, these findings identified the eye-localized Cry2 as an indispensable component and a likely photoreceptor of the directional GMF response. Our study is thus a clear step forward in deciphering the in vivo effects of GMF and supports the interaction of underlying mechanism with the visual system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.