ArticleProceedings of the National Academy of Sciences of the United States of America2016
Genomic reconstruction of the history of extant populations of India reveals five distinct ancestral components and a complex structure.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 3 of them syntheses that pooled it.
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97 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Evaluating the risk of dapsone hypersensitivity syndrome in Nepalese Leprosy Patients via HLA-B* 13:01 screening using real-time PCR and comparative meta-analysis of international data.PLoS neglected tropical diseases · 2026Pooled it
- Human genetic diversity across South Asian populations: A systematic review and meta-analysis.Medicine · 2025Pooled it
- Screening and diagnosis of gestational diabetes in India: a systematic review and meta-analysis.Acta diabetologica · 2018Pooled it
- A comprehensive portrait of Y-STR diversity of Indian populations and comparison with 129 worldwide populations.Scientific reports · 2018Trial
- Genomic reconstruction of the Pakistani Roma reveals dual South Asian ancestry, medieval bottlenecks, and the early dispersal routes of the Romani people.Human genomics · 2026Article
- Layers in the sand: The genetic imprint of migration, culture, and Indus craft in the Thar Desert.HGG advances · 2026Article
- Reconstruction of the genetic history of the Austro-Asiatic- and Dravidian-speaking tribal populations of South Asia.iScience · 2026Article
- Identifying Adaptive Footprints in the Presence of Demographic Uncertainty.Genome biology and evolution · 2026Article
- Age at Menarche Among Mizo Women in Aizawl, Mizoram: A Secular Trend Across Five Birth-Decade Cohorts (1960-2007).Cureus · 2026Article
- Reflections on the Human Genome Diversity Project: a conversation with Marcus W. Feldman, Henry T. Greely, and Mary-Claire King.Genetics · 2026Article
- Comparative GWAS using global and Indian Reference Panels reveals non-coding drivers of COVID-19 severity and mortality.PLoS neglected tropical diseases · 2026Article
- Northeast india: genetic inconsistency across ethnicity and geography.Molecular genetics and genomics : MGG · 2026Article
- Recommendations for responsible use of population descriptors in polygenic risk score development.Nature genetics · 2025Review
- Coancestry superposed on admixed populations yields measures of relatedness at individual-level resolution.PLoS computational biology · 2025Article
- Novel 4400-year-old ancestral component in a tribe speaking a Dravidian language.European journal of human genetics : EJHG · 2025Article
- Not by Selection Alone: Expanding the Scope of Gene-Culture Coevolution.Evolutionary anthropology · 2025Review
- Exploring the genetic footprints of the gotra system in the Koṅkaṇī Sārasvata Brahmins.Molecular genetics and genomics : MGG · 2025Article
- Forensic Characterization, Genomic Variability and Ancestry Analysis of Six Populations from Odisha Using mtDNA SNPs and Autosomal STRs.Biochemical genetics · 2025Article
- Article
- Mapping genetic diversity with the GenomeIndia project.Nature genetics · 2025Article
37 more citing papers are in PubMed but not listed here.
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Abstract
India, occupying the center stage of Paleolithic and Neolithic migrations, has been underrepresented in genome-wide studies of variation. Systematic analysis of genome-wide data, using multiple robust statistical methods, on (i) 367 unrelated individuals drawn from 18 mainland and 2 island (Andaman and Nicobar Islands) populations selected to represent geographic, linguistic, and ethnic diversities, and (ii) individuals from populations represented in the Human Genome Diversity Panel (HGDP), reveal four major ancestries in mainland India. This contrasts with an earlier inference of two ancestries based on limited population sampling. A distinct ancestry of the populations of Andaman archipelago was identified and found to be coancestral to Oceanic populations. Analysis of ancestral haplotype blocks revealed that extant mainland populations (i) admixed widely irrespective of ancestry, although admixtures between populations was not always symmetric, and (ii) this practice was rapidly replaced by endogamy about 70 generations ago, among upper castes and Indo-European speakers predominantly. This estimated time coincides with the historical period of formulation and adoption of sociocultural norms restricting intermarriage in large social strata. A similar replacement observed among tribal populations was temporally less uniform.
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