Evidence map›Paper›PMID 26811234›Full record

ReviewCellular and molecular life sciences : CMLS2016

Articular cartilage tissue engineering: the role of signaling molecules.

Heenam Kwon, Nikolaos K Paschos, Jerry C Hu, Kyriacos Athanasiou

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 2 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 109 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Heenam KwonDepartment of Biomedical Engineering, University of California Davis, One Shields Avenue, Davis, CA, 95616, USA.
Nikolaos K PaschosDepartment of Biomedical Engineering, University of California Davis, One Shields Avenue, Davis, CA, 95616, USA.
Jerry C HuDepartment of Biomedical Engineering, University of California Davis, One Shields Avenue, Davis, CA, 95616, USA.
Kyriacos AthanasiouDepartment of Biomedical Engineering, University of California Davis, One Shields Avenue, Davis, CA, 95616, USA. athanasiou@ucdavis.edu.
University of California, Davis · US

Funding

Self-assembling process in tissue engineering of articular cartilageR01AR067821 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ATHANASIOU, KYRIACOS A · 2015 to 2019
$1.9M
Engineering Lubrication in Tissue Engineered CartilageR01AR061496 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ATHANASIOU, KYRIACOS A, REDDI, AKEPATI HARI · 2011 to 2014
$1.3M
NIAMS NIH HHS AR061496NIAMS NIH HHS R01 AR061496NIAMS NIH HHS R01 AR067821
6 · The paper itself

Abstract

Effective early disease modifying options for osteoarthritis remain lacking. Tissue engineering approach to generate cartilage in vitro has emerged as a promising option for articular cartilage repair and regeneration. Signaling molecules and matrix modifying agents, derived from knowledge of cartilage development and homeostasis, have been used as biochemical stimuli toward cartilage tissue engineering and have led to improvements in the functionality of engineered cartilage. Clinical translation of neocartilage faces challenges, such as phenotypic instability of the engineered cartilage, poor integration, inflammation, and catabolic factors in the arthritic environment; these can all contribute to failure of implanted neocartilage. A comprehensive understanding of signaling molecules involved in osteoarthritis pathogenesis and their actions on engineered cartilage will be crucial. Thus, while it is important to continue deriving inspiration from cartilage development and homeostasis, it has become increasingly necessary to incorporate knowledge from osteoarthritis pathogenesis into cartilage tissue engineering.

Indexed as

ChondrogenesisSignal TransductionAnimalsCartilage, ArticularHumansOsteoarthritisTissue EngineeringArticular cartilageCartilage developmentOsteoarthritisSignaling moleculesTissue engineering

Identifiers

PMID26811234
PMCPMC5435375
OpenAlexW2252330823

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.