ArticleMagma (New York, N.Y.)2016
(31)P CSI of the human brain in healthy subjects and tumor patients at 9.4 T with a three-layered multi-nuclear coil: initial results.
Article in Magma (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 36 citations in OpenAlex.
- FunctionalNMR in biomedicine · 2025Article
- A proton birdcage coil integrated with interchangeable single loops for multi-nuclear MRI/MRS.Journal of Zhejiang University. Science. B · 2024Article
- Multinuclear Magnetic Resonance Spectroscopy at Ultra-High-Field: Assessing Human Cerebral Metabolism in Healthy and Diseased States.Metabolites · 2023Review
- A cryogenic 14-channelMagnetic resonance in medicine · 2023Article
- Simultaneous detection of metabolite concentration changes, water BOLD signal and pH changes during visual stimulation in the human brain at 9.4T.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- GLINT: GlucoCEST in neoplastic tumors at 3 T-clinical results of GlucoCEST in gliomas.Magma (New York, N.Y.) · 2022Article
- Deuterium metabolic imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution.NeuroImage · 2021Article
- 7 Tesla and Beyond: Advanced Methods and Clinical Applications in Magnetic Resonance Imaging.Investigative radiology · 2021Review
- 31-Phosphorus Magnetic Resonance Spectroscopy in Evaluation of Glioma and Metastases in 3T MRI.The Indian journal of radiology & imaging · 2021Article
- PCA denoising and Wiener deconvolution ofMagnetic resonance in medicine · 2021Article
- Accelerated MR spectroscopic imaging-a review of current and emerging techniques.NMR in biomedicine · 2021Review
- Review
- Magnetic Resonance pH Imaging in Stroke - Combining the Old With the New.Frontiers in physiology · 2021Article
- Mapping an Extended Metabolic Profile of Gliomas Using High-ResolutionFrontiers in neurology · 2021Article
- An in vivo multimodal feasibility study in a rat brain tumour model using flexible multinuclear MR and PET systems.EJNMMI physics · 2020Article
- A Review of Non-IEEE open journal of engineering in medicine and biology · 2020Article
- Key clinical benefits of neuroimaging at 7T.NeuroImage · 2018Review
- InterleavedNMR in biomedicine · 2018Article
- Magnetic Resonance Imaging of Phosphocreatine and Determination of BOLD Kinetics in Lower Extremity Muscles using a Dual-Frequency Coil Array.Scientific reports · 2016Article
- From ultrahigh to extreme field magnetic resonance: where physics, biology and medicine meet.Magma (New York, N.Y.) · 2016Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveInvestigation of the feasibility and performance of phosphorus ((31)P) magnetic resonance spectroscopic imaging (MRSI) at 9.4 T with a three-layered phosphorus/proton coil in human normal brain tissue and tumor. MATERIALS AND
methodsA multi-channel (31)P coil was designed to enable MRSI of the entire human brain. The performance of the coil was evaluated by means of electromagnetic field simulations and actual measurements. A 3D chemical shift imaging approach with a variable repetition time and flip angle was used to increase the achievable signal-to-noise ratio of the acquired (31)P spectra. The impact of the resulting k-space modulation was investigated by simulations. Three tumor patients and three healthy volunteers were scanned and differences between spectra from healthy and cancerous tissue were evaluated qualitatively.
resultsThe high sensitivity provided by the 27-channel (31)P coil allowed acquiring CSI data in 22 min with a nominal voxel size of 15 × 15 × 15 mm(3). Shimming and anatomical localization could be performed with the integrated four-channel proton dipole array. The amplitudes of the phosphodiesters and phosphoethanolamine appeared reduced in tumorous tissue for all three patients. A neutral or slightly alkaline pH was measured within the brain lesions.
conclusionThese initial results demonstrate that (31)P 3D CSI is feasible at 9.4 T and could be performed successfully in healthy subjects and tumor patients in under 30 min.
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