SynthesisJournal of the American Heart Association2016
Diagnostic Accuracy of Tissue Doppler Index E/e' for Evaluating Left Ventricular Filling Pressure and Diastolic Dysfunction/Heart Failure With Preserved Ejection Fraction: A Systematic Review and Meta-Analysis.
Synthesis in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03854071 (Development of Novel Physiological CMR Methods in Health and Disease), which is not on this map. Cited by 89 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Development of Novel Physiological CMR Methods in Health and Disease
Who cites it
89 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Meta-analysis of echocardiographic quantification of left ventricular filling pressure.ESC heart failure · 2021Pooled it
- Evaluation of Cardiac Function in Women With a History of Preeclampsia: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2019Pooled it
- Is echocardiography valid and reproducible in patients with atrial fibrillation? A systematic review.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2017Pooled it
- What Is the Evidence That the Tissue Doppler Index E/e' Reflects Left Ventricular Filling Pressure Changes After Exercise or Pharmacological Intervention for Evaluating Diastolic Function? A Systematic Review.Journal of the American Heart Association · 2017Pooled it
- Effect of exercise on diastolic function in heart failure patients: a systematic review and meta-analysis.Heart failure reviews · 2017Pooled it
- Pirfenidone in heart failure with preserved ejection fraction: a randomized phase 2 trial.Nature medicine · 2021Trial
- Extended-Release Oral Milrinone for the Treatment of Heart Failure With Preserved Ejection Fraction.Journal of the American Heart Association · 2020Trial
- On the search for the right definition of heart failure with preserved ejection fraction.Cardiology journal · 2020Trial
- Artificial intelligence-enabled electrocardiography for detection of left ventricular diastolic dysfunction: a systematic review and meta-analysis.European heart journal. Digital health · 2026Review
- Beyond E/e': A Physiology-Based Framework for Emerging Echocardiographic Biomarkers in the Noninvasive Assessment of Left Ventricular Filling Pressure.Echocardiography (Mount Kisco, N.Y.) · 2026Review
- Triglyceride-Glucose-Waist-to-Height Ratio Index and Left Ventricular Diastolic Function in Military Athletes.JACC. Advances · 2026Article
- PLAX-Only M-Mode Scoring System for Risk Stratification of Moderate-to-Severe Left Ventricular Diastolic Dysfunction: A Retrospective Diagnostic Study.Echocardiography (Mount Kisco, N.Y.) · 2026Article
- Imaging-based detection and prediction of radiation-induced cardiac toxicity: a narrative review.BJR open · 2026Review
- Evaluation of Prognosis and Risk Factors of Fulminant Myocarditis Complicated with Malignant Arrhythmia.Journal of cardiovascular development and disease · 2025Article
- Head to head comparison of left atrial and ventricular strain at rest in the prediction of exercise-induced elevated left ventricular filling pressure in patients without obvious myocardial ischemia.Journal of echocardiography · 2025Article
- Diabetic cardiomyopathy: a comprehensive review of diagnosis, management, and future directions.Diabetology & metabolic syndrome · 2025Review
- Society for Maternal-Fetal Medicine Consult Series #73: Diagnosis and management of right and left heart failure during pregnancy and postpartum.Pregnancy (Hoboken, N.J.) · 2025Article
- Preadmission CHAJournal of clinical medicine · 2025Article
- Advancing Cardiovascular Risk Stratification and Functional Assessment: A Narrative Review of CPET and ESE Applications.Healthcare (Basel, Switzerland) · 2025Review
- Exercise Hemodynamics and Sex-Specific Data in Asymptomatic Adults: An Exploratory Pilot Study.Diagnostics (Basel, Switzerland) · 2025Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
backgroundTissue Doppler index E/e' is used clinically and in multidisciplinary research for estimation of left ventricular filling pressure (LVFP) and diastolic dysfunction (DD)/heart failure with preserved ejection fraction (HFpEF). Its diagnostic accuracy is not well studied. METHODS AND
resultsFrom the PubMed, Scopus, Embase, and Cochrane databases, we identified 24 studies reporting E/e' and invasive LVFP in preserved EF (≥50%). In random-effects models, E/e' had poor to mediocre linear correlation with LVFP. Summary sensitivity and specificity (with 95% CIs) for the American Society of Echocardiography-recommended E/e' cutoffs (lateral, mean, and septal, respectively) to identify elevated LVFP was estimated by using hierarchical summary receiver operating characteristic analysis. Summary sensitivity was 30% (9-48%), 37% (13-61%), and 24% (6-46%), and summary specificity was 92% (82-100%), 91% (80-99%), and 98% (92-100%). Positive likelihood ratio (LR+) was <5 for lateral and mean E/e'. LR+ was slightly >10 for septal E/e' obtained from 4 studies (cumulative sample size <220). For excluding elevated LVFP, summary sensitivity for E/e' (lateral, mean, and septal, respectively) was 64% (38-86%), 36% (3-74%), and 50% (14-81%), while summary specificity was 73% (54-89%), 83% (49-100%), and 89% (66-100%). Because of data set limitations, meaningful inference for identifying HFpEF by using E/e' could not be drawn. With the use of quality assessment tool for diagnostic accuracy studies (Quality Assessment of Diagnostic Accuracy Studies questionnaire), we found substantial risks of bias and/or applicability.
conclusionsThere is insufficient evidence to support that E/e' can reliably estimate LVFP in preserved EF. The diagnostic accuracy of E/e' to identify/exclude elevated LVFP and DD/HFpEF is limited and requires further validation in a well-designed prospective clinical trial.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.