ArticlePhysiological reports2016
The nuclear receptor REV-ERBα represses the transcription of growth/differentiation factor 10 and 15 genes in rat endometrium stromal cells.
Article in Physiological reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- BMAL1 Dysregulation as a Contributing Mechanism Linking Obesity to Oocyte and Endometrial Dysfunction in IVF.International journal of molecular sciences · 2026Review
- Multilevel transcriptional regulation of embryonic sex determination and dosage compensation by the X-signal element sex-1.Genetics · 2026Article
- Role of circadian clock in female embryo implantation.Frontiers in cell and developmental biology · 2025Review
- Multi-level transcriptional regulation of embryonic sex determination and dosage compensation by the X-signal elementbioRxiv : the preprint server for biology · 2024Article
- Local production of 17β-oestradiol in the endometrium during the implantation window: a pilot study.Reproduction & fertility · 2023Article
- GDF15: a potential therapeutic target for type 1 diabetes.Expert opinion on therapeutic targets · 2022Review
- Chrono-communication and cardiometabolic health: The intrinsic relationship and therapeutic nutritional promises.Frontiers in endocrinology · 2022Review
- The Role of GDF15 as a Myomitokine.Cells · 2021Review
- Regulation of diurnal energy balance by mitokines.Cellular and molecular life sciences : CMLS · 2021Review
- Recent advances in modulators of circadian rhythms: an update and perspective.Journal of enzyme inhibition and medicinal chemistry · 2020Review
- Estradiol-17β-Induced Changes in the Porcine Endometrial Transcriptome In Vivo.International journal of molecular sciences · 2020Article
- Melatonin Promotes Uterine and Placental Health: Potential Molecular Mechanisms.International journal of molecular sciences · 2019Review
- Functional polymorphisms in circadian positive feedback loop genes predict postsurgical prognosis of gastric cancer.Cancer medicine · 2019Article
- Research progress on circadian clock genes in common abdominal malignant tumors.Oncology letters · 2017Article
- The nuclear receptor REV-ERBα represses the transcription of growth/differentiation factor 10 and 15 genes in rat endometrium stromal cells.Physiological reports · 2016Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellular oscillators in the uterus play critical roles in the gestation processes of mammals through entraining of the clock proteins to numerous downstream genes, including growth/differentiation factor (Gdf)10 and Gdf15. The expression of Gdf10 and Gdf15 is significantly increased in the uterus during decidualization, but the mechanism underlying the regulation of Gdf gene expression in the uterus is poorly understood. Here, we focused on the function of the cellular oscillators in the expression of Gdf family by using uterine endometrial stromal cells (UESCs) isolated from pregnant Per2-dLuc transgenic rats. A significant decline of Per2-dLuc bioluminescence activity was induced in in vitro decidualized UESCs, and concomitantly the expression of canonical clock genes was downregulated. Conversely, the expression of Gdf10 and Gdf15 of the Gdf was upregulated. In UESCs transfected with Bmal1-specific siRNA, in which Rev-erbα expression was downregulated, Gdf10 and Gdf15 were upregulated. However, Gdf5, Gdf7, and Gdf11 were not significantly affected by Bmal1 silencing. The expression of Gdf10 and Gdf15 was enhanced after treatment with a REV-ERBα antagonist in the presence or absence of progesterone. Chromatin immunoprecipitation-PCR analysis revealed the inhibitory effect of REV-ERBα on the expression of Gdf10 and Gdf15 in UESCs by recognizing their gene promoters. Collectively, our findings indicate that the attenuation of REV-ERBα leads to an upregulation of Gdf10 and Gdf15 in decidual cells, in which cellular oscillators are impaired. Our results provide novel evidence regarding the functions of cellular oscillators regulating the expression of downstream genes during the differentiation of UESCs.
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