Evidence map›Paper›PMID 26810939›Full record

ArticleAmerican journal of surgery2016

Outcomes after resection of cortisol-secreting adrenocortical carcinoma.

Georgios Antonios Margonis, Yuhree Kim, Thuy B Tran, Lauren M Postlewait, Shishir K Maithel, Tracy S Wang, Jason A Glenn, Ioannis Hatzaras, Rivfka Shenoy, John E Phay and 17 more

Open access · greenAbstract readComparative StudyEvaluation StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Hormonal functional status and prognostic stratification in adrenocortical carcinoma: a single-center retrospective cohort study.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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  14. Low Protein Expression of bothInternational journal of molecular sciences · 2021
    Article
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  20. The impact of patient-, disease-, and treatment-related factors on survival in patients with adrenocortical carcinoma.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 14 institutions in 1 country.

Georgios Antonios MargonisDepartment of Surgery, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 688, Baltimore, MD, 21287, USA.
Yuhree KimDepartment of Surgery, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 688, Baltimore, MD, 21287, USA.
Thuy B TranDepartment of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Lauren M PostlewaitDepartment of Surgery, Emory University, Atlanta, GA, USA.
Shishir K MaithelDepartment of Surgery, Emory University, Atlanta, GA, USA.
Tracy S WangDepartment of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Jason A GlennDepartment of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Ioannis HatzarasDepartment of Surgery, New York University School of Medicine, New York, NY, USA.
Rivfka ShenoyDepartment of Surgery, New York University School of Medicine, New York, NY, USA.
John E PhayDepartment of Surgery, The Ohio State University, Columbus, OH, USA.
Kara KeplingerDepartment of Surgery, The Ohio State University, Columbus, OH, USA.
Ryan C FieldsDepartment of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Linda X JinDepartment of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Sharon M WeberDepartment of General Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Ahmed SalemDepartment of General Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Jason K SicklickDepartment of Surgery, University of California San Diego, San Diego, CA, USA.
Shady GadDepartment of Surgery, University of California San Diego, San Diego, CA, USA.
Adam C YoppDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
John C MansourDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Quan-Yang DuhDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Natalie SeiserDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Carmen C SolorzanoDepartment of Surgery, Vanderbilt University, Nashville, TN, USA.
Colleen M KiernanDepartment of Surgery, Vanderbilt University, Nashville, TN, USA.
Konstantinos I VotanopoulosDepartment of Surgery, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Edward A LevineDepartment of Surgery, Wake Forest School of Medicine, Winston-Salem, NC, USA.
George A PoultsidesDepartment of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Timothy M PawlikDepartment of Surgery, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 688, Baltimore, MD, 21287, USA. Electronic address: tpawlik1@jhmi.edu.
Emory University · USJohns Hopkins University · USMedical College of Wisconsin · USNew York University · USStanford University · USThe Ohio State University · USThe University of Texas Southwestern Medical Center · USUniversity of California, San Diego · USUniversity of California, San Francisco · USUniversity of Wisconsin–Madison · USVanderbilt University · USWake Forest University · USWashington University in St. Louis · USJohns Hopkins Medicine · US

Funding

Novel Allosteric Kinase Inhibitors Target Imatinib-Resistant GISTK08CA168999 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SICKLICK, JASON KEITH · 2014 to 2018
$888k
Defining the Germline Genomic Landscape of a Novel GIST Multi-tumor SyndromeR21CA192072 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SICKLICK, JASON KEITH · 2016 to 2017
$399k
NCI NIH HHS K08 CA168999NCI NIH HHS R21 CA192072
6 · The paper itself

Abstract

backgroundWe sought to define the impact of cortisol-secreting status on outcomes after surgical resection of adrenocortical carcinoma (ACC).

methodsThe U.S ACC group database was queried to identify patients who underwent ACC resection between 1993 and 2014. The short-term and long-term outcomes were assessed.

resultsThe incidence of all functional and cortisol-secreting tumors was 40.6% and 22.6%, respectively. On multivariable analysis, cortisol secretion remained associated with an increased risk of postoperative complications (odds ratio = 2.25, 95 % confidence interval = 1.04 to 4.88; P = .04). At a median follow-up of 17.6 months, 118 patients (50.4%) had developed a recurrence. On multivariable analysis, after adjusting for patient and disease-related factors cortisol secretion independently predicted shorter recurrence-free survival (Hazard ratio = 2.05, 95% confidence interval = 1.16 to 3.60; P = .01).

conclusionsCortisol secretion was associated with an increased risk of postoperative morbidity. Recurrence remains high among patients with ACC after surgery; cortisol secretion was independently associated with a shorter recurrence-free survival. Tailoring postoperative surveillance of ACC patients based on their cortisol secreting status may be important.

Indexed as

Adrenal Cortex NeoplasmsAdrenalectomyAdrenocortical CarcinomaAdultAnalysis of VarianceCause of DeathDatabases, FactualDisease-Free SurvivalFemaleHumansHydrocortisoneKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisPostoperative ComplicationsHydrocortisoneAdrenocorticalCarcinomaCortisolOutcomes

Identifiers

PMID26810939
PMCPMC4957943
OpenAlexW2274958028

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.