Evidence map›Paper›PMID 26810186›Full record

ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016

Genetic variations in interleukin-6 polymorphism and the association with susceptibility and overall survival of osteosarcoma.

Yunlong Qi, Chengbin Zhao, Hongxi Li, Benning Zhang, Kazuhiro Tada, Hiroyuki Abe, Midori Tada

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Oxidative medicine and cellular longevity · 2018
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yunlong QiDepartment of Orthopedics, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150001, China. qiylhb2323@sina.com.
Chengbin ZhaoDepartment of Orthopedics, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
Hongxi LiDepartment of Orthopedics, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
Benning ZhangDepartment of Immunology, The Institute of Medical Oncology, Harbin Medical University, Harbin, 150001, China.
Kazuhiro TadaDepartment of Immunology, The Institute of Medical Oncology, Harbin Medical University, Harbin, 150001, China.
Hiroyuki AbeKudan Clinic, The Institute of Medical Oncology, Kudan, Japan.
Midori TadaDepartment of Immunology, The Institute of Medical Oncology, Kudan, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interleukin-6 (IL-6), a central proinflammatory cytokine, may be involved in both development and progression of many human malignancies. Therefore, we aimed to evaluate any associations of IL-6 gene polymorphisms with susceptibility and overall survival of osteosarcoma in a Chinese population. A total of 412 subjects, including 206 patients with osteosarcoma and 206 healthy controls, were recruited and were assessed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in this study. Significant differences of genotype distribution were observed between osteosarcoma cases and controls at the IL-6 -174 G/C genotypes. Compared with the homozygote GG, the heterozygous GC genotype was associated with significantly increased risk for osteosarcoma (odds ratio [OR] = 1.58, 95 % confidence interval [CI] = 1.13-3.05, p = 0.028); the CC genotype was associated with increased risk for osteosarcoma (OR = 1.57, 95 % CI = 1.21-3.26, p = 0.022). Moreover, the genotype CC of IL-6 -174 G/C carried a higher risk of osteosarcoma metastasis and later Enneking stages, compared with the GG genotype. The IL-6 -174 G/C genotype was associated with risk for development and metastasis of osteosarcoma in Chinese Han population.

Indexed as

AdultBiomarkers, TumorBone NeoplasmsCase-Control StudiesFemaleFollow-Up StudiesGenetic Predisposition to DiseaseGenotypeHumansInterleukin-6MaleNeoplasm MetastasisNeoplasm StagingOsteosarcomaPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthBiomarkers, TumorIL6 protein, humanInterleukin-6IL-6OsteosarcomaSingle-nucleotide polymorphismSusceptibility

Identifiers

PMID26810186

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.