Evidence map›Paper›PMID 26810113›Full record

ReviewJournal of nephrology2016

Membranous glomerulonephritis: histological and serological features to differentiate cancer-related and non-related forms.

Corrado Murtas, Gian Marco Ghiggeri

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of nephrology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Folic acid-induced animal model of kidney disease.Animal models and experimental medicine · 2021
    Review
  7. Perspectives in membranous nephropathy.Cell and tissue research · 2021
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
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  15. Article
  16. Malignancy in Membranous Nephropathy: Evaluation of Incidence.International journal of nephrology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Corrado MurtasDivision of Nephrology and Dialysis, Ospedale San Martino, ASL 5, via Rockefeller, 09170, Oristano, Italy. cormur@gmail.com.ORCID http://orcid.org/0000-0001-7801-6596
Gian Marco GhiggeriDivision of Nephrology Dialysis and Transplantation, Istituto Giannina Gaslini, Genoa, Italy.
Istituto Giannina Gaslini · ITOspedale Martini · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Membranous nephropathy is a frequent cause of nephrotic syndrome in adults. In most patients, it appears as a primary renal disease but in about 20 % of cases membranous nephropathy is associated with systemic conditions such as systemic lupus erythematosus, infections or cancer, or with drug exposure. Reliable differentiation between primary and secondary membranous nephropathy has important implications for the patient, because of different therapeutic approaches between the different forms. The recent in vivo definition of glomerular targets of autoimmunity in idiopathic membranous nephropathy represented a real breakthrough and nowadays more than one podocyte antigen is considered in some way implicated in the pathogenesis of human membranous nephropathy. Specific antibodies against all these components have been detected in serum of patients and could become biomarkers of membranous nephropathy and/or of disease activity. In this brief review, we discuss the usefulness of newly described autoantibodies in the differential diagnosis of secondary membranous nephropathy. Histological clues for recognizing the two pathological entities are also analysed with regard to the available scientific evidence on this issue. Our evaluation shows that more research is needed to identify the best approach to reach a correct diagnosis of primary or secondary membranous nephropathy.

Indexed as

AutoantibodiesBiomarkersDiagnosis, DifferentialGlomerulonephritis, MembranousHumansKidney GlomerulusKidney NeoplasmsPodocytesReceptors, Phospholipase A2AutoantibodiesBiomarkersReceptors, Phospholipase A2Anti-PLA2rAnti-podocyte antibodiesIgG subclassesMembranous nephropathySecondary membranous nephropathy

Identifiers

PMID26810113
OpenAlexW2252607539

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.