Evidence map›Paper›PMID 26810033›Full record

ArticleHuman vaccines & immunotherapeutics2016

Transdermal immunization of P. falciparum surface antigen (MSP-119) via elastic liposomes confers robust immunogenicity.

Rajeev K Tyagi, Neeraj K Garg, Sarat K Dalai, Amit Awasthi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rajeev K Tyagia Department of Global Health , College of Public Health, University of South Florida , Tampa , FL , USA.
Neeraj K Gargb Drug Delivery Research Group, University Institute of Pharmaceutical Sciences, UGC center of Advanced Studies, Panjab University , Chandigarh , India.
Sarat K Dalaic Institute of Science, Nirma University , Ahmedabad , Gujarat , India.
Amit Awasthid Translational Health Science and Technology Institute (an autonomous institute of Department of Biotechnology , Govt. of India), NCR Biotech Science , Faridabad , India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As transdermal immunization results in poor immunogenicity, which is attributed to poor permeability of antigens through the skin, we believed ultradeformable lipid vesicles (elastic liposome) might address the challenges encountered during transdermal immunization. The elastic liposome, versatile carrier, proves better vehicle for transcutaneous delivery of protein, peptide and nucleic acid antigens. Our recently published article (1) is suggestive of improved immunogenicity of carboxyl-terminal 19 kDa fragment of merozoite surface protein-1 (PfMSP-119) of Plasmodium falciparum when administered subcutaneously via elastic liposomes ( Fig. 1 ).

Indexed as

Immunogenicity, VaccineAdjuvants, ImmunologicAdministration, CutaneousAnimalsAntibodies, ProtozoanAntigens, ProtozoanImmunity, CellularImmunity, HumoralImmunizationLangerhans CellsLipidsLiposomesMalaria, FalciparumMalaria VaccinesMerozoite Surface Protein 1MiceAdjuvants, ImmunologicAntibodies, ProtozoanAntigens, ProtozoanLipidsLiposomesMalaria VaccinesMerozoite Surface Protein 1Cellular and humoral immunityElastic liposomeImmunizationLangerhans cellsMSP-119Transdermal deliveryVaccine

Identifiers

PMID26810033
PMCPMC4962934

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.