Evidence map›Paper›PMID 26809977›Full record

ArticleJournal of endocrinological investigation2016

Vitamin D status in children and adolescents with autoimmune thyroiditis.

K A Metwalley, H S Farghaly, T Sherief, A Hussein

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Article in Journal of endocrinological investigation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 5 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 5 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  6. Article
  7. Review
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  9. Review
  10. Autoimmune Thyroiditis and Vitamin D.International journal of molecular sciences · 2024
    Review
  11. Article
  12. Article
  13. Review
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  15. Article
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  17. Review
  18. Article
  19. The Role of Vitamin D in Thyroid Diseases.International journal of molecular sciences · 2017
    Review
  20. Sunshine vitamin and thyroid.Reviews in endocrine & metabolic disorders · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

K A MetwalleyDepartment of Pediatrics, Faculty of Medicine, Assiut University, B.O 71111, Assiut, Egypt. kotb72@gmail.com.
H S FarghalyDepartment of Pediatrics, Faculty of Medicine, Assiut University, B.O 71111, Assiut, Egypt.
T SheriefDepartment of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt.
A HusseinDepartment of Pediatrics, Faculty of Medicine, Assiut University, B.O 71111, Assiut, Egypt.
Assiut University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin D deficiency is a global health problem. Its role as an immune modulator has been recently emphasized. There is increasing evidence for the significant role of vitamin D in reducing the incidence of autoimmune diseases. However, little is known about the status of vitamin D in children and adolescents with autoimmune thyroiditis (AIT).

objectiveThe goal of the present study was to assess vitamin D status in Egyptian children and adolescents with AIT and to explore its relation to biomarkers of autoimmunity and thyroid function.

designA prevalence case-control study that included 56 children with AIT and 56 healthy, age- and sex-matched subjects that served as the control group. The following was done for all participants: thorough history, physical examination, thyroid ultrasound, measurement of thyroid-stimulating hormone (TSH), free thyroxin (FT4), anti-thyroid peroxidase antibodies (TPOAb), anti-thyroglobulin antibody (TgAb) and assessment of serum 25-hydroxy vitamin D (25OHD) level.

resultsOvert hypothyroidism was detected in 42/56 while subclinical hypothyroidism was detected in 14/56 of the studied patients. Vitamin D deficiency rate was significantly higher in the AIT group compared to the control subjects (71.4 vs 21.4 %, P < 0.001). In AIT group, the mean level of 25OHD was significantly lower compared to the control group (16.2 ± 8.2 vs 33.9 ± 12.7 nmol/L, P < 0.001). The difference was more evident in patients with overt hypothyroidism than those with subclinical hypothyroidism (P < 0.01). There were significant negative correlations between serum 25OHD and age, duration of the disease, BMI, anti-TPOAb, anti-TGAb and TSH (P < 0.001 each). On the other hand, serum 25OHD correlated positively with FT4 levels. While 25OHD level was an independent risk factor for AIT, it failed to qualify as an independent risk for the progression of AIT to overt hypothyroidism after adjustment for other potential confounding factors; age, sex and BMI.

conclusionsLow serum vitamin D is significantly associated with AIT in Egyptian children. However, vitamin D level is not an independent risk for the progression of AIT to overt hypothyroidism. BMI may have an influence on serum 25OHD levels.

Indexed as

AdolescentBiomarkersEnzyme-Linked Immunosorbent AssayFemaleHumansIncidenceMaleThyroid Function TestsThyroiditis, AutoimmuneVitamin DVitamin D DeficiencyVitaminsBiomarkersVitamin DVitaminsAnti-thyroid peroxidaseAutoimmune thyroiditisOvert hypothyroidismVitamin D deficiency

Identifiers

PMID26809977
OpenAlexW2297480617

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.