Trial reportDiabetes research and clinical practice2016
Systolic blood pressure variability and lower extremity amputation in a non-elderly population with diabetes.
Trial report in Diabetes research and clinical practice, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Expression and diagnostic value of lncRNA MALAT1 and NLRP3 in lower limb atherosclerosis in diabetes.BMC endocrine disorders · 2024Article
- Association between oral microbial nitrate metabolism and poor prognosis in acute ischemic stroke patients with a history of hypertension.Journal of oral microbiology · 2024Article
- Cost-Savings Associated with Multi-Disciplinary Team Approach for Reducing Macrovascular and Microvascular Complications in Patients with Type 2 Diabetes: A Predictive Model.ClinicoEconomics and outcomes research : CEOR · 2024Article
- Correlations Among Visit-to-Visit Blood Pressure Variability and Treatment With Antihypertensive Medication With Long-Term Adverse Outcomes in a Large Veteran Cohort.American journal of hypertension · 2021Article
- Preoperative outpatient blood pressure variability predicts postoperative mortality, readmission and morbidity after surgery.American journal of surgery · 2020Article
- Retrospective cohort study of the relationship between systolic blood pressure variability and multiple sclerosis disability.BMJ open · 2020Article
- Reply.Journal of hypertension · 2019Article
- Increasing SBP variability is associated with an increased risk of developing incident diabetic foot ulcers.Journal of hypertension · 2018Article
- Marine collagen peptides reduce endothelial cell injury in diabetic rats by inhibiting apoptosis and the expression of coupling factor 6 and microparticles.Molecular medicine reports · 2017Article
- High Systolic and Diastolic Blood Pressure Variability Is Correlated with the Occurrence of Peripheral Arterial Disease in the First Decade following a Diagnosis of Type 2 Diabetes Mellitus: A New Biomarker from Old Measurement.BioMed research international · 2016Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveSystolic blood pressure (SBP) variability is emerging as a new risk factor for cardiovascular diseases, diabetic nephropathy, and other atherosclerotic conditions. Our objective is to examine whether it has any prognostic value for lower-extremity amputations. RESEARCH DESIGN AND
methodsThis is a nested case-control study of a cohort of patients with diabetes aged<60 years and treated in the US Department of Veterans Healthcare system in 2003. They were followed over five years for any above-ankle (major) amputations. For each case with a major amputation (event), we randomly selected up to five matched controls based on age, sex, race/ethnicity, and calendar time. SBP variability was computed using three or more blood pressure measures taken during the one-year period before the event. Patients were classified into quartiles according to their SBP variability.
resultsThe study sample included 1038 cases and 2932 controls. Compared to Quartile 1 (lowest variability), Quartile 2 had 1.4 times (OR=1.44, 95% CI=1.00-2.07) and Quartiles 3 and 4 (highest) had 2.5 times (OR for Quartile 3=2.62, 95% CI=1.85-3.72; OR for Quartile 4=2.50, 95% CI=1.74-3.59) higher risk of major amputation (P for trend<0.001). This gradient relationship held in both normotensive and hypertensive groups as well as for individuals without prior peripheral vascular disease.
conclusionsThis is the first study to show a significant graded relationship between SBP variability and risk of major amputation among non-elderly persons with diabetes.
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