Evidence map›Paper›PMID 26809484›Full record

ReviewVeterinary immunology and immunopathology2016

Comparison of probiotic lactobacilli and bifidobacteria effects, immune responses and rotavirus vaccines and infection in different host species.

Anastasia N Vlasova, Sukumar Kandasamy, Kuldeep S Chattha, Gireesh Rajashekara, Linda J Saif

Open access · greenAbstract readComparative StudyReview
In one paragraph

Review in Veterinary immunology and immunopathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 2 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 2 syntheses or guidelines pooled it, 187 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. High-dose Probiotic Mix ofOpen forum infectious diseases · 2024
    Trial
  4. Trial
  5. Trial
  6. Trial
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Biomedicines · 2026
    Article
  15. Article
  16. Review
  17. Article
  18. Synbiotic-ContainingIranian journal of public health · 2025
    Article
  19. Towards EffectiveInternational journal of molecular sciences · 2025
    Review
  20. Review

31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anastasia N VlasovaFood Animal Health Research Program, The Ohio Agricultural Research and Development Center, Veterinary Preventive Medicine Department, The Ohio State University, Wooster, OH, USA. Electronic address: vlasova.1@osu.edu.
Sukumar KandasamyFood Animal Health Research Program, The Ohio Agricultural Research and Development Center, Veterinary Preventive Medicine Department, The Ohio State University, Wooster, OH, USA.
Kuldeep S ChatthaFood Animal Health Research Program, The Ohio Agricultural Research and Development Center, Veterinary Preventive Medicine Department, The Ohio State University, Wooster, OH, USA.
Gireesh RajashekaraFood Animal Health Research Program, The Ohio Agricultural Research and Development Center, Veterinary Preventive Medicine Department, The Ohio State University, Wooster, OH, USA.
Linda J SaifFood Animal Health Research Program, The Ohio Agricultural Research and Development Center, Veterinary Preventive Medicine Department, The Ohio State University, Wooster, OH, USA. Electronic address: saif.2@osu.edu.
The Ohio State University · US

Funding

Gut microflora: Impact on neonatal immunity, viral gastroenteritis and vaccinesR01AI099451 · NIAID · OHIO STATE UNIVERSITY · PI RAJASHEKARA, GIREESH, SAIF, LINDA J. · 2012 to 2016
$2.2M
Lactogenic immunity/probiotics: Effect on neonatal gut immunityR21AT004716 · NCCIH · OHIO STATE UNIVERSITY · PI SAIF, LINDA J. · 2009 to 2010
$474k
NCCIH NIH HHS R21 AT004716NIAID NIH HHS R01 AI099451PHS HHS R01 R01A1099451
6 · The paper itself

Abstract

Different probiotic strains of Lactobacillus and Bifidobacterium genera possess significant and widely acknowledged health-promoting and immunomodulatory properties. They also provide an affordable means for prevention and treatment of various infectious, allergic and inflammatory conditions as demonstrated in numerous human and animal studies. Despite the ample evidence of protective effects of these probiotics against rotavirus (RV) infection and disease, the precise immune mechanisms of this protection remain largely undefined, because of limited mechanistic research possible in humans and investigated in the majority of animal models. Additionally, while most human clinical probiotic trials are well-standardized using the same strains, uniform dosages, regimens of the probiotic treatments and similar host age, animal studies often lack standardization, have variable experimental designs, and non-uniform and sometime limited selection of experimental variables or observational parameters. This review presents selected data on different probiotic strains of lactobacilli and bifidobacteria and summarizes the knowledge of their immunomodulatory properties and the associated protection against RV disease in diverse host species including neonates.

Indexed as

AnimalsBifidobacteriumHumansLactobacillusProbioticsRotavirus InfectionsRotavirus VaccinesSpecies SpecificityRotavirus VaccinesBifidobacteriaDiarrheaImmunomodulationLactobacilliProbioticsRotavirus

Identifiers

PMID26809484
PMCPMC4818210
OpenAlexW2287681468

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.