Evidence map›Paper›PMID 26809191›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2016

The effects of body mass index on the hereditary influences that determine peak bone mass in mother-daughter pairs (KNHANES V).

K M Kim, Y J Kim, S H Choi, S Lim, J H Moon, J H Kim, S W Kim, H C Jang, C S Shin

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Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

K M KimDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Y J KimDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
S H ChoiDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
S LimDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
J H MoonDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
J H KimDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
S W KimDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
H C JangDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
C S ShinDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. csshin@snu.ac.kr.
Seoul National University · KRSeoul National University Bundang Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledA daughter's bone mineral density (BMD) is significantly correlated with her mother's BMD, but the daughter's body mass index (BMI) could modulate this association. Maternal inheritance dominantly affects daughters with a lower BMI, but BMI could compensate for hereditary influences in daughters with a higher BMI in terms of daughter's BMD.

introductionAchieving optimal peak bone mass at a young age is the best way to protect against future osteoporosis and subsequent fractures. Although environmental components influence bone mass accrual, but peak bone mass is largely programmed by inheritance. The aims of this study were to investigate the influence of maternal inheritance on the daughter's bone mass and to assess whether these influences differ according to the daughter's body mass index (BMI).

methodsWe used data obtained from the 2010 Korean National Health and Nutrition Examination Survey V and included 187 mother-daughter pairs. Bone mineral density (BMD) was measured at the lumbar spine (LS), femur neck (FN), and total hip (TH) by using dual-energy X-ray absorptiometry (DXA). The daughter group was stratified into two groups according to the mean BMI (21.4 kg/m(2)).

resultsThe daughters' BMD correlated significantly with both their BMI and their mothers' Z-score for each skeletal site. In the daughters with a lower BMI (≤21.4 kg/m(2)), the BMDs at the FN and TH were affected more by the mothers' Z-score than by the daughters' BMI. Meanwhile, the influence of the daughters' BMI on their BMD was higher than that of their mothers' Z-score in daughters with a higher BMI (>21.4 kg/m(2)). Moreover, the mothers' Z-scores were a significant predictor of their daughters having Z-scores < -1.0 only in daughters with a lower BMI.

conclusionsThis study suggests that maternal inheritance is an important determinant of the daughters' bone mass, but that this hereditary factor may vary according to the daughters' BMI.

Indexed as

Body Mass IndexAbsorptiometry, PhotonAdultBone DensityFemaleFemur NeckHipHumansLumbar VertebraeMiddle AgedMothersNuclear FamilyNutrition SurveysRepublic of KoreaYoung AdultBody mass indexBone mineral densityGenetic inheritanceOsteoporosisPeak bone mass

Identifiers

PMID26809191
OpenAlexW2263950627

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.