ArticlePloS one2016
Spatiotemporal Cluster Patterns of Hand, Foot, and Mouth Disease at the County Level in Mainland China, 2008-2012.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Small-scale spatiotemporal epidemiology of notifiable infectious diseases in China: a systematic review.BMC infectious diseases · 2022Pooled it
- Epidemiological characteristics and spatiotemporal analysis of hand-foot-mouth disease in Shandong Province, China.International health · 2026Article
- Age-stratified clinical characteristics of hand, foot, and mouth disease in children and its guiding value for diagnosis and treatment.Frontiers in pediatrics · 2026Article
- Impact of meteorological factors on the incidence of hand, foot, and mouth disease caused by major enterovirus pathogens: a distributed lag nonlinear analysis in Fujian Province, China.BMC infectious diseases · 2025Article
- Transmission components of hand, foot, and mouth disease in Guangdong Province and their association with meteorological factors: a modelling study.BMC infectious diseases · 2025Article
- Spatiotemporal Distribution of Hand, Foot, and Mouth Disease and the Influence of Air Pollutants and Socioeconomic Factors on Incidence in Fujian, China.Tropical medicine and infectious disease · 2025Article
- Analyzing the spatiotemporal effects of meteorological factors on hand, foot and mouth disease using mixed geographically and temporally weighted autoregressive models.Scientific reports · 2025Article
- Influencing factors of hand, foot, and mouth disease based on structural equation modeling in Hubei, China.Scientific reports · 2025Article
- Epidemiology and spatiotemporal analysis of acute hemorrhagic conjunctivitis in Zhejiang province, China (2004-2023).Frontiers in public health · 2025Article
- Epidemiological changes of scarlet fever before, during and after the COVID-19 pandemic in Chongqing, China: a 19-year surveillance and prediction study.BMC public health · 2024Article
- Spatiotemporal Changes and Influencing Factors of Hand, Foot, and Mouth Disease in Guangzhou, China, From 2013 to 2022: Retrospective Analysis.JMIR public health and surveillance · 2024Article
- Epidemiology and etiology of hand, foot, and mouth disease in Zhengzhou, China, from 2009 to 2021.Infectious medicine · 2024Article
- Spatiotemporal patterns and risk mapping of provincial hand, foot, and mouth disease in mainland China, 2014-2017.Frontiers in public health · 2024Article
- Influence of social and meteorological factors on hand, foot, and mouth disease in Sichuan Province.BMC public health · 2023Article
- Epidemiological characteristics and spatiotemporal patterns of hand, foot, and mouth disease in Hubei, China from 2009 to 2019.PloS one · 2023Article
- Spatiotemporal cluster patterns of hand, foot, and mouth disease at the province level in mainland China, 2011-2018.PloS one · 2022Article
- Epidemiological characteristics and spatiotemporal analysis of hand-foot-mouth diseases from 2010 to 2019 in Zibo city, Shandong, China.BMC public health · 2021Article
- Control measures during the COVID-19 outbreak reduced the transmission of hand, foot, and mouth disease.Journal of safety science and resilience = An quan ke xue yu ren xing (Ying wen) · 2021Article
- Assessment of Temperature-Hand, Foot, and Mouth Disease Association and Its Variability across Urban and Rural Populations in Wuxi, China: A Distributed Lag Nonlinear Analysis.The American journal of tropical medicine and hygiene · 2020Article
- National Epidemiology and Evolutionary History of Four Hand, Foot and Mouth Disease-Related Enteroviruses in China from 2008 to 2016.Virologica Sinica · 2020Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHand, foot, and mouth disease (HFMD) is known to be a highly contagious childhood illness. In recent years, the number of reported cases of HFMD has significantly increased in mainland China. This study aims at the epidemiological features, spatiotemporal patterns of HMFD at the county/district level in mainland China.
methodsData on reported HFMD cases for each county from 1 January 2008 to 31 December 2012 were obtained from the Chinese Center for Disease Control and Prevention. Cluster analysis, spatial autocorrelation, and retrospective scan methods were used to explore the spatiotemporal patterns of the disease.
resultsThe annual incidences varied greatly among the counties, ranging from 0 to 74.31‰ with the median of 5.42‰ (interquartile range: 1.54‰-13.55‰) during 2008-2012 in mainland China. Counties close to provincial capital cities generally had higher incidences than rural counties. A seasonal distribution was observed between the northern and southern China, of which dual epidemic were shown in southern China and usually only one in northern China. Based on the global and local spatial autocorrelation analysis, we found that the spatial distribution of HFMD was presented a significant clustering pattern for each year (P<0.001), and hotspots of the disease were mostly distributed in coastal provinces of China. The retrospective scan statistic further identified the dynamics of spatiotemporal clustering areas of the disease, which were mainly distributed in the counties of eastern and southern China, as well as provincial capitals and their surrounding counties.
conclusionsThe spatiotemporal clustering areas of the disease identified in this way were relatively stable, and imminent public health planning and resource allocation should be focused within those areas.
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