ArticlePloS one2016
Low Incidence of Synchronous or Metachronous Tumors after Endoscopic Submucosal Dissection for Early Gastric Cancer with Undifferentiated Histology.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparison of long-term outcomes of endoscopic submucosal dissection and surgery for undifferentiated-type early gastric cancer meeting the expanded criteria: a systematic review and meta-analysis.Surgical endoscopy · 2022Pooled it
- Assessment of Outcomes From 1-Year Surveillance After Detection of Early Gastric Cancer Among Patients at High Risk in Japan.JAMA network open · 2022Trial
- Early gastric cancer of young patients treated by endoscopic submucosal dissection: focusing on the different characteristics and prognosis of elderly patients.Surgical endoscopy · 2024Article
- Metachronous gastric neoplasm beyond 5 years after endoscopic resection for early gastric cancer.Surgical endoscopy · 2023Article
- Incidence and treatment outcomes of metachronous gastric cancer occurring after curative endoscopic submucosal dissection of undifferentiated-type early gastric cancer: Japan Clinical Oncology Group study-post hoc analysis of JCOG1009/1010.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2021Article
- Incidence and prognosis of undifferentiated cancers of the digestive system: a population-based cohort study.Annals of translational medicine · 2021Article
- White globe appearance is an endoscopic predictive factor for synchronous multiple gastric cancer.Annals of gastroenterology · 2021Article
- Prognostic factors for ESD of early gastric cancers: a systematic review and meta-analysis.Endoscopy international open · 2020Review
- Long-term outcomes of endoscopic submucosal dissection versus surgery for treating early gastric cancer of undifferentiated-type.Medicine · 2020Article
- Endoscopic submucosal dissection for undifferentiated-type early gastric cancer: short- and long-term outcomes.Surgical endoscopy · 2018Article
- The Comparison between Endoscopic Submucosal Dissection and Surgery in Gastric Cancer: A Systematic Review and Meta-Analysis.Gastroenterology research and practice · 2018Review
- Risk factors for lymph node metastasis of early gastric cancers in patients younger than 40.Medicine · 2017Observational
- Gastric Adenocarcinoma: A Multimodal Approach.Frontiers in surgery · 2017Review
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGastric cancer with undifferentiated histology has different clinicopathologic characteristics compared to differentiated type gastric cancer. We aimed to compare the risk of synchronous or metachronous tumors after curative resection of early gastric cancer (EGC) via endoscopic submucosal dissection (ESD), according to the histologic differentiation of the primary lesion.
methodsClinicopathological data of patients with initial-onset EGC curatively resected via ESD between January 2007 and November 2014 in a single institution were reviewed. We analyzed the incidence of synchronous or metachronous tumors after ESD with special reference to the differentiation status of the primary lesion.
resultsOf 1,560 patients with EGC who underwent curative resection via ESD, 1,447 had differentiated type cancers, and 113 had undifferentiated type cancers. The cumulative incidence of metachronous or synchronous tumor after ESD was higher in the differentiated cancer group than in the undifferentiated cancer group (P = 0.008). Incidence of metachronous or synchronous tumor was 4.8% and 1.2% per person-year in the differentiated and undifferentiated cancer groups, respectively. The Cox proportional hazard model revealed that undifferentiated cancers were associated with a low risk of synchronous or metachronous tumors after adjusting for confounding variables (hazard ratio [95% confidence interval] = 0.287 [0.090-0.918]).
conclusionsThe rate of synchronous or metachronous tumors after curative ESD was significantly lower for undifferentiated cancers compare to differentiated cancers. These findings suggest that ESD should be actively considered as a possible treatment for undifferentiated type EGCs.
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