ArticlePloS one2016
Accuracy of Non-Enhanced CT in Detecting Early Ischemic Edema Using Frequency Selective Non-Linear Blending.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Acute Infarct Core Volume Estimation on Noncontrast Computed Tomography With a Deep Learning Algorithm.Stroke (Hoboken, N.J.) · 2025Article
- Improved Visualization and Quantification of Net Water Uptake in Recent Small Subcortical Infarcts in the Thalamus Using Computed Tomography.Diagnostics (Basel, Switzerland) · 2023Article
- Model-Based Iterative Reconstruction (MBIR) for ASPECT Scoring in Acute Stroke Patients Selection: Comparison to rCBV and Follow-Up Imaging.Tomography (Ann Arbor, Mich.) · 2022Article
- Detecting brain lesions in suspected acute ischemic stroke with CT-based synthetic MRI using generative adversarial networks.Annals of translational medicine · 2022Article
- Accuracy of thin-slice model-based iterative reconstruction designed for brain CT to diagnose acute ischemic stroke in the middle cerebral artery territory: a multicenter study.Neuroradiology · 2021Article
- Minute changes of cerebral parenchymal non-contrast computed tomography attenuation reflect cerebral volume alterations of blood.The neuroradiology journal · 2021Article
- Mesenteric ischemia: what the radiologist needs to know.Cardiovascular diagnosis and therapy · 2019Review
- Using Correlative Properties of Neighboring Pixels to Improve Gray-White Differentiation in Pediatric Head CT Images.AJNR. American journal of neuroradiology · 2018Article
- Frequency-selective non-linear blending for the computed tomography diagnosis of acute gangrenous cholecystitis: Pilot retrospective evaluation.European journal of radiology open · 2018Article
- Improved CT-detection of acute bowel ischemia using frequency selective non-linear image blending.Acta radiologica open · 2017Article
- Imaging of cerebral ischemic edema and neuronal death.Neuroradiology · 2017Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIschemic brain edema is subtle and hard to detect by computed tomography within the first hours of stroke onset. We hypothesize that non-enhanced CT (NECT) post-processing with frequency-selective non-linear blending ("best contrast"/BC) increases its accuracy in detecting edema and irreversible tissue damage (infarction).
methodsWe retrospectively analyzed the NECT scans of 76 consecutive patients with ischemic stroke (exclusively middle cerebral artery territory-MCA) before and after post-processing with BC both at baseline before reperfusion therapy and at follow-up (5.73±12.74 days after stroke onset) using the Alberta Stroke Program Early CT Score (ASPECTS). We assessed the differences in ASPECTS between unprocessed and post-processed images and calculated sensitivity, specificity, and predictive values of baseline NECT using follow-up CT serving as reference standard for brain infarction.
resultsNECT detected brain tissue hypoattenuation in 35 of 76 patients (46.1%). This number increased to 71 patients (93.4%) after post-processing with BC. Follow-up NECT confirmed brain infarctions in 65 patients (85.5%; p = 0.012). Post-processing increased the sensitivity of NECT for brain infarction from 35/65 (54%) to 65/65 (100%), decreased its specificity from 11/11 (100%) to 7/11 (64%), its positive predictive value (PPV) from 35/35 (100%) to 65/69 (94%) and increased its accuracy 46/76 (61%) to 72/76 (95%).
conclusionsThis post-hoc analysis suggests that post-processing of NECT with BC may increase its sensitivity for ischemic brain damage significantly.
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