ArticleComparative biochemistry and physiology. Part A, Molecular & integrative physiology2016
Bohr effect and temperature sensitivity of hemoglobins from highland and lowland deer mice.
Article in Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Local adaptation, plasticity, and evolved resistance to hypoxic cold stress in high-altitude deer mice.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Multi-omic Analyses Shed Light on The Genetic Control of High-altitude Adaptation in Sheep.Genomics, proteomics & bioinformatics · 2024Article
- Local adaptation, plasticity, and evolved resistance to hypoxic cold stress in high-altitude deer mice.bioRxiv : the preprint server for biology · 2024Article
- Convergent High OAnimals : an open access journal from MDPI · 2024Article
- Article
- Altitude acclimatization, hemoglobin-oxygen affinity, and circulatory oxygen transport in hypoxia.Molecular aspects of medicine · 2022Review
- Genetic variation in haemoglobin is associated with evolved changes in breathing in high-altitude deer mice.The Journal of experimental biology · 2022Article
- Comparison of hematological traits and oxygenation properties of hemoglobins from highland and lowland Asiatic toad (Bufo gargarizans).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Review
- Correlation between convection requirement and carotid body responses to hypoxia and hemoglobin affinity: comparison between two rat strains.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- High-Altitude Adaptation: Mechanistic Insights from Integrated Genomics and Physiology.Molecular biology and evolution · 2021Review
- The adaptive benefit of evolved increases in hemoglobin-OBMC biology · 2021Article
- Physiological Genomics of Adaptation to High-Altitude Hypoxia.Annual review of animal biosciences · 2021Review
- Life Ascending: Mechanism and Process in Physiological Adaptation to High-Altitude Hypoxia.Annual review of ecology, evolution, and systematics · 2019Article
- Evolution of physiological performance capacities and environmental adaptation: insights from high-elevation deer mice (Journal of mammalogy · 2019Article
- Acclimatization of low altitude-bred deer mice ( Peromyscus maniculatus) to high altitude.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Regulation of blood oxygen transport in hibernating mammals.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Review
- The Greenland shark Somniosus microcephalus-Hemoglobins and ligand-binding properties.PloS one · 2017Article
- Alteration of the α1β2/α2β1 subunit interface contributes to the increased hemoglobin-oxygen affinity of high-altitude deer mice.PloS one · 2017Article
- Hemoglobin-oxygen affinity in high-altitude vertebrates: is there evidence for an adaptive trend?The Journal of experimental biology · 2016Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
An important means of physiological adaptation to environmental hypoxia is an increased oxygen (O2) affinity of the hemoglobin (Hb) that can help secure high O2 saturation of arterial blood. However, the trade-off associated with a high Hb-O2 affinity is that it can compromise O2 unloading in the systemic capillaries. High-altitude deer mice (Peromyscus maniculatus) have evolved an increased Hb-O2 affinity relative to lowland conspecifics, but it is not known whether they have also evolved compensatory mechanisms to facilitate O2 unloading to respiring tissues. Here we investigate the effects of pH (Bohr effect) and temperature on the O2-affinity of high- and low-altitude deer mouse Hb variants, as these properties can potentially facilitate O2 unloading to metabolizing tissues. Our experiments revealed that Bohr factors for the high- and low-altitude Hb variants are very similar in spite of the differences in O2-affinity. The Bohr factors of deer mouse Hbs are also comparable to those of other mammalian Hbs. In contrast, the high- and low-altitude variants of deer mouse Hb exhibited similarly low temperature sensitivities that were independent of red blood cell anionic cofactors, suggesting an appreciable endothermic allosteric transition upon oxygenation. In conclusion, high-altitude deer mice have evolved an adaptive increase in Hb-O2 affinity, but this is not associated with compensatory changes in sensitivity to changes in pH or temperature. Instead, it appears that the elevated Hb-O2 affinity in high-altitude deer mice is compensated by an associated increase in the tissue diffusion capacity of O2 (via increased muscle capillarization), which promotes O2 unloading.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.