ArticleHealth physics2016
Physical Considerations for Understanding Responses of Biological Systems to Low Doses of Ionizing Radiation: Nucleosome Clutches Constitute a Heterogeneous Distribution of Target Volumes.
Article in Health physics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Population Studies and Molecular Mechanisms of Human Radioadaptive Capabilities: Is It Time to Rethink Radiation Safety Standards?International journal of molecular sciences · 2024Review
- Evaluation of micronuclei and antioxidant status in hospital radiation workers occupationally exposed to low-dose ionizing radiation.BMC health services research · 2023Article
- Low-dose ionizing radiation as a hormetin: experimental observations and therapeutic perspective for age-related disorders.Biogerontology · 2021Review
- Health Impacts of Low-Dose Ionizing Radiation: Current Scientific Debates and Regulatory Issues.Dose-response : a publication of International Hormesis SocietyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Humans are exposed to low doses of ionizing radiation that arise from a variety of sources. The response of biological systems to low doses of ionizing radiation depend on many factors. Some of the physical factors include distribution of the radiation sources, radiation track structure, structure and dimensions of the biological targets, temporal patterns of radiation exposure(s), absorbed dose rate and total absorbed dose. Recent discoveries suggest that assumptions regarding the structure of an important biological target, namely chromatin, may not be correct. It is now believed that chromatin fiber consists of heterogeneous groups of nucleosomes called clutches, and the distribution of clutch sizes differs between somatic cells and stem cells. This shift in paradigm may have implications for radiation target theory and its explanation of observations of clustered DNA damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.