Evidence map›Paper›PMID 26808837›Full record

ArticlePloS one2016

Development of an Arthroscopic Joint Capsule Injury Model in the Canine Shoulder.

David Kovacevic, Andrew R Baker, Susan M Staugaitis, Myung-Sun Kim, Eric T Ricchetti, Kathleen A Derwin

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

David KovacevicDepartment of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio, United States of America.
Andrew R BakerDepartment of Biomedical Engineering and the Orthopaedic Research Center, Cleveland Clinic, Cleveland, Ohio, United States of America.
Susan M StaugaitisDepartment of Pathology, Cleveland Clinic, Cleveland, Ohio, United States of America.
Myung-Sun KimDepartment of Orthopaedic Surgery, Chonnam National University College of Medicine, Gwangju, Republic of Korea.
Eric T RicchettiDepartment of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio, United States of America.
Kathleen A DerwinDepartment of Biomedical Engineering and the Orthopaedic Research Center, Cleveland Clinic, Cleveland, Ohio, United States of America.
Cleveland Clinic · USChonnam National University · KR

Funding

Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1TR000439
6 · The paper itself

Abstract

backgroundThe natural history of rotator cuff tears can be unfavorable as patients develop fatty infiltration and muscle atrophy that is often associated with a loss of muscle strength and shoulder function. To facilitate study of possible biologic mechanisms involved in early degenerative changes to rotator cuff muscle and tendon tissues, the objective of this study was to develop a joint capsule injury model in the canine shoulder using arthroscopy.

methodsArthroscopic surgical methods for performing a posterior joint capsulectomy in the canine shoulder were first defined in cadavers. Subsequently, one canine subject underwent bilateral shoulder joint capsulectomy using arthroscopy, arthroscopic surveillance at 2, 4 and 8 weeks, and gross and histologic examination of the joint at 10 weeks.

resultsThe canine subject was weight-bearing within eight hours after index and follow-up surgeries and had no significant soft tissue swelling of the shoulder girdle or gross lameness. Chronic synovitis and macroscopic and microscopic evidence of pathologic changes to the rotator cuff bony insertions, tendons, myotendinous junctions and muscles were observed.

conclusionsThis study demonstrates feasibility and proof-of-concept for a joint capsule injury model in the canine shoulder. Future work is needed to define the observed pathologic changes and their role in the progression of rotator cuff disease. Ultimately, better understanding of the biologic mechanisms of early progression of rotator cuff disease may lead to clinical interventions to halt or slow this process and avoid the more advanced and often irreversible conditions of large tendon tears with muscle fatty atrophy.

Indexed as

AnimalsArthroscopyDisease Models, AnimalDogsFemaleJoint CapsuleJoint DiseasesShoulder Joint

Identifiers

PMID26808837
PMCPMC4725771
OpenAlexW2272724358

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.