ArticlePloS one2016
Translational Control of UIS4 Protein of the Host-Parasite Interface Is Mediated by the RNA Binding Protein Puf2 in Plasmodium berghei Sporozoites.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Preparing for Transmission: Gene Regulation inFrontiers in cellular and infection microbiology · 2020Review
- Protein-RNA interactions important for Plasmodium transmission.PLoS pathogens · 2019Review
- Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites.Nature communications · 2019Article
- CXCR4 regulatesThe Journal of experimental medicine · 2019Article
- AFrontiers in cellular and infection microbiology · 2019Article
- The Promise of Systems Biology Approaches for Revealing Host Pathogen Interactions in Malaria.Frontiers in microbiology · 2017Review
- Translational regulation in blood stages of the malaria parasite Plasmodium spp.: systems-wide studies pave the way.Wiley interdisciplinary reviews. RNA · 2016Review
- Recent advances in malaria genomics and epigenomics.Genome medicine · 2016Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
UIS4 is a key protein component of the host-parasite interface in the liver stage of the rodent malaria parasite Plasmodium berghei and required for parasite survival after invasion. In the infectious sporozoite, UIS4 protein has variably been shown to be translated but also been reported to be translationally repressed. Here we show that uis4 mRNA translation is regulated by the P. berghei RNA binding protein Pumilio-2 (PbPuf2 or Puf2 from here on forward) in infectious salivary gland sporozoites in the mosquito vector. Using RNA immunoprecipitation we show that uis4 mRNA is bound by Puf2 in salivary gland sporozoites. In the absence of Puf2, uis4 mRNA translation is de-regulated and UIS4 protein expression upregulated in salivary gland sporozoites. Here, using RNA immunoprecipitation, we reveal the first Puf2-regulated mRNA in this parasite.
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