ArticlePloS one2016
Two Horizontally Transferred Xenobiotic Resistance Gene Clusters Associated with Detoxification of Benzoxazolinones by Fusarium Species.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed.
- Synthetic communities of maize root bacteria interact and redirect benzoxazinoid metabolization.mSphere · 2025Article
- Adaptation of Fusarium Head Blight Pathogens to Changes in Agricultural Practices and Human Migration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The lactonase BxdA mediates metabolic specialisation of maize root bacteria to benzoxazinoids.Nature communications · 2024Article
- Insights into the genomic and functional divergence of NAT gene family to serve microbial secondary metabolism.Scientific reports · 2024Article
- Article
- Article
- Endophyte genomes support greater metabolic gene cluster diversity compared with non-endophytes in Trichoderma.PloS one · 2023Article
- Bioactive Nitrosylated and NitratedMolecules (Basel, Switzerland) · 2022Article
- Transcriptional Profiles of a Foliar Fungal Endophyte (mSystems · 2022Article
- A taxonomically representative strain collection to explore xenobiotic and secondary metabolism in bacteria.PloS one · 2022Article
- Transcriptomic Responses ofFrontiers in fungal biology · 2022Article
- Transcriptomic Response ofFrontiers in fungal biology · 2022Article
- Biotransformation ability of endophytic fungi: from species evolution to industrial applications.Applied microbiology and biotechnology · 2021Review
- Disarming the Host: Detoxification of Plant Defense Compounds During Fungal Necrotrophy.Frontiers in plant science · 2021Review
- Pyrrocidine, a molecular off switch for fumonisin biosynthesis.PLoS pathogens · 2020Article
- The Transcriptional Profile ofPathogens (Basel, Switzerland) · 2019Article
- Deletion of the benzoxazinoid detoxification gene NAT1 in Fusarium graminearum reduces deoxynivalenol in spring wheat.PloS one · 2019Article
- Specialized plant biochemistry drives gene clustering in fungi.The ISME journal · 2018Article
- Multiple independent origins for a subtelomeric locus associated with growth rate inIMA fungus · 2018Article
- Fungal Lactamases: Their Occurrence and Function.Frontiers in microbiology · 2017Review
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Microbes encounter a broad spectrum of antimicrobial compounds in their environments and often possess metabolic strategies to detoxify such xenobiotics. We have previously shown that Fusarium verticillioides, a fungal pathogen of maize known for its production of fumonisin mycotoxins, possesses two unlinked loci, FDB1 and FDB2, necessary for detoxification of antimicrobial compounds produced by maize, including the γ-lactam 2-benzoxazolinone (BOA). In support of these earlier studies, microarray analysis of F. verticillioides exposed to BOA identified the induction of multiple genes at FDB1 and FDB2, indicating the loci consist of gene clusters. One of the FDB1 cluster genes encoded a protein having domain homology to the metallo-β-lactamase (MBL) superfamily. Deletion of this gene (MBL1) rendered F. verticillioides incapable of metabolizing BOA and thus unable to grow on BOA-amended media. Deletion of other FDB1 cluster genes, in particular AMD1 and DLH1, did not affect BOA degradation. Phylogenetic analyses and topology testing of the FDB1 and FDB2 cluster genes suggested two horizontal transfer events among fungi, one being transfer of FDB1 from Fusarium to Colletotrichum, and the second being transfer of the FDB2 cluster from Fusarium to Aspergillus. Together, the results suggest that plant-derived xenobiotics have exerted evolutionary pressure on these fungi, leading to horizontal transfer of genes that enhance fitness or virulence.
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