ArticleEpidemiology (Cambridge, Mass.)2016
Childhood and Adolescent Pesticide Exposure and Breast Cancer Risk.
Article in Epidemiology (Cambridge, Mass.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Environmental exposures and breast cancer risk in the context of underlying susceptibility: A systematic review of the epidemiological literature.Environmental research · 2020Pooled it
- Impact of DDT on women's health in Bangladesh: escalating breast cancer risk and disturbing menstrual cycle.Frontiers in public health · 2024Article
- Endocrine-disrupting compounds and metabolomic reprogramming in breast cancer.Journal of biochemical and molecular toxicology · 2023Review
- Brief research report pesticide occupational exposure leads to significant inflammatory changes in normal mammary breast tissue.Frontiers in public health · 2023Article
- The importance of addressing early life environmental exposures in cancer epidemiology.Current epidemiology reports · 2022Article
- Somatic DNA Damage Response and Homologous Repair Gene Alterations and Its Association With Tumor Variant Burden in Breast Cancer Patients With Occupational Exposure to Pesticides.Frontiers in oncology · 2022Article
- Why We Will Continue to Lose Our Battle with Cancers If We Do Not Stop Their Triggers from Environmental Pollution.International journal of environmental research and public health · 2021Review
- Exposure to Endocrine Disrupting Chemicals and Risk of Breast Cancer.International journal of molecular sciences · 2020Review
- Article
- Herbicide, fumigant, and fungicide use and breast cancer risk among farmers' wives.Environmental epidemiology (Philadelphia, Pa.) · 2020Article
- In utero DDT exposure and breast density in early menopause by maternal history of breast cancer.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- Serum concentrations of DDE, PCBs, and other persistent organic pollutants and mammographic breast density in Triana, Alabama, a highly exposed population.Environmental research · 2020Article
- A case-control study of breast cancer risk and ambient exposure to pesticides.Environmental epidemiology (Philadelphia, Pa.) · 2019Article
- Self-reported residential pesticide use and survival after breast cancer.International journal of hygiene and environmental health · 2019Article
- Childhood Residential and Agricultural Pesticide Exposures in Relation to Adult-Onset Rheumatoid Arthritis in Women.American journal of epidemiology · 2018Article
- A prospective study of cancer risk among Agricultural Health Study farm spouses associated with personal use of organochlorine insecticides.Environmental health : a global access science source · 2017Article
- Serum Vitamin D and Risk of Breast Cancer within Five Years.Environmental health perspectives · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundTo date, epidemiologic studies have not strongly supported an association between pesticide exposure and breast cancer. However, few previous studies had the ability to assess specific time periods of exposure. Studies that relied on adult serum levels of metabolites of organochlorine pesticides may not accurately reflect exposure during developmental periods. Furthermore, exposure assessment often occurred after diagnosis and key tumor characteristics, such as hormone receptor status, have rarely been available to evaluate tumor subtype-specific associations. We examined the association between pesticide exposure during childhood and adolescence and breast cancer risk in the prospective Sister Study cohort (N = 50,884 women) to assess this relation by tumor subtype.
methodsDuring an average 5-year follow-up, 2,134 incident invasive and in situ breast cancer diagnoses were identified. Residential and farm exposure to pesticides were self-reported at study enrollment during standardized interviews. Multivariable hazard ratios and 95% confidence intervals for breast cancer risk were calculated with Cox proportional hazards regression.
resultsHRs were near null for the association between childhood/adolescent pesticide exposure and breast cancer risk overall or among ER+/PR+ invasive tumors. However, among women who were ages 0-18 before the ban of dichlordiphenyltrichloroethane in the US, exposure to fogger trucks or planes was associated with a hazard ratio = 1.3 for premenopausal breast cancer (95% confidence interval: 0.92, 1.7).
conclusionThese findings do not support an overall association between childhood and adolescent pesticide exposure and breast cancer risk. However, modest increases in breast cancer risk were associated with acute events in a subgroup of young women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.