ArticlePloS one2016
Postprandial Hypertriglyceridemia Predicts Development of Insulin Resistance Glucose Intolerance and Type 2 Diabetes.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 53 citations in OpenAlex.
- Vitamin DEuropean journal of clinical nutrition · 2018Trial
- An XGBoost-based model for detecting undiagnosed type 2 diabetes using routine physical and lifestyle data from a multi-center Chinese population.Frontiers in medicine · 2026Article
- The modified cardiometabolic index as a simple screening tool for cardiovascular disease risk: a cohort study.Scientific reports · 2025Article
- The fat-mass and obesity-associated gene rs9939609 T allele is prominent among the native Mexican population and is associated with risk for Type 2 diabetes and metabolic dysfunction-associated steatotic liver disease.Frontiers in nutrition · 2025Article
- Plasma protein N-glycome composition associates with postprandial lipaemic response.BMC medicine · 2023Review
- Real-World Effectiveness and Safety of Hydrogen Inhalation in Chinese Patients with Type 2 Diabetes: A Single-Arm, Retrospective Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Oral fat tolerance testing identifies abnormal pancreatic β-cell function and insulin resistance in individuals with normal glucose tolerance.Journal of diabetes investigation · 2022Article
- Metabolomics of Type 1 and Type 2 Diabetes: Insights into Risk Prediction and Mechanisms.Current diabetes reports · 2022Review
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- Effectiveness and safety of hydrogen inhalation as an adjunct treatment in Chinese type 2 diabetes patients: A retrospective, observational, double-arm, real-life clinical study.Frontiers in endocrinology · 2022Observational
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- Molecular hydrogen improves type 2 diabetes through inhibiting oxidative stress.Experimental and therapeutic medicine · 2020Article
- Association of PPARγ gene expression with postprandial hypertriglyceridaemia and risk of type 2 diabetes mellitus.Endocrine · 2020Article
- Dairy Foods and Dairy Fats: New Perspectives on Pathways Implicated in Cardiometabolic Health.Advances in nutrition (Bethesda, Md.) · 2020Review
- The association between triglycerides and ectopic fat obesity: An inverted U-shaped curve.PloS one · 2020Article
- The association of metabolic syndrome components and diabetes mellitus: evidence from China National Stroke Screening and Prevention Project.BMC public health · 2019Article
- High prevalence of nonalcoholic steatohepatitis and abnormal liver stiffness in a young and obese Mexican population.PloS one · 2019Article
- A 7-day high-PUFA diet reduces angiopoietin-like protein 3 and 8 responses and postprandial triglyceride levels in healthy females but not males: a randomized control trial.BMC nutrition · 2019Article
- The Association between Persistent Hypertriglyceridemia and the Risk of Diabetes Development: The Kangbuk Samsung Health Study (Endocrinol Metab 2018;33:55-61, Yu Hyun Kwon et al.).Endocrinology and metabolism (Seoul, Korea) · 2018Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin resistance (IR) and type 2 diabetes mellitus (T2DM) have been found to be associated with postprandial hypertriglyceridemia (PPHTg). However, whether PPHTg can cause IR and diabetes is not clear. We therefore investigated the role of PPHTg in development of T2DM in rat model of T2DM. 96 male Wistar rats were randomized into four groups (24 rats each). Control Group A, high sucrose diet (HSD) Group B, HSD+Pioglitazone (10 mg/kg/day) Group C and HSD+Atorvastatin (20 mg/kg/day) Group D. Fat and glucose tolerance tests were done at regular intervals in all groups besides insulin and body weight measurement. At 26 weeks, low dose streptozotocin (15 mg/kg, i.p.) was given to half of the rats. All rats were followed up till 48 weeks. PPHTg developed as early as week 2 in Group B and stabilized by week 14. Group B displayed highest PPHTg compared to other groups. Atorvastatin treatment (Group D) abolished PPHTg which became comparable to controls, pioglitazone treatment partially blunted PPHTg resulting in intermediate PPHTg. Group B with highest PPHTg showed highest subsequent IR, glucose intolerance (GI) and highest incidence of prediabetes at week 26 and diabetes at week 34 and 46 compared to other groups. Group D rats displayed lower IR, GI, low incidence of prediabetes and diabetes at these time points compared to Groups B and C. ROC analysis showed that triglyceride area under the curve of each time point significantly predicts the risk of diabetes. Present study provides the evidence that PPHTg predicts the development of IR, GI and T2DM in rat model of diet induced T2DM.
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