Evidence map›Paper›PMID 26808472›Full record

ReviewExpert opinion on drug delivery2016

Heat effects on drug delivery across human skin.

Jinsong Hao, Priyanka Ghosh, S Kevin Li, Bryan Newman, Gerald B Kasting, Sam G Raney

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Expert opinion on drug delivery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Therapeutic peptides and proteins: Status and developments in drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Pharmacokinetic Profile of Fentanyl in the Koala (Animals : an open access journal from MDPI · 2021
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jinsong Haoa Department of Pharmaceutical Science and Research , School of Pharmacy, Marshall University , Huntington , WV , USA.
Priyanka Ghoshb Office of Research and Standards, Office of Generic Drugs , Center for Drug Evaluation and Research, United States Food and Drug Administration , Silver Spring , MD , USA.
S Kevin Lic Division of Pharmaceutical Sciences , James L Winkle College of Pharmacy, University of Cincinnati , Cincinnati , OH , USA.
Bryan Newmanb Office of Research and Standards, Office of Generic Drugs , Center for Drug Evaluation and Research, United States Food and Drug Administration , Silver Spring , MD , USA.
Gerald B Kastingc Division of Pharmaceutical Sciences , James L Winkle College of Pharmacy, University of Cincinnati , Cincinnati , OH , USA.
Sam G Raneyb Office of Research and Standards, Office of Generic Drugs , Center for Drug Evaluation and Research, United States Food and Drug Administration , Silver Spring , MD , USA.

Funding

Tiered Testing Strategy for Assessing Thermal Effects on Transdermal ProductsU01FD004942 · FDA · UNIVERSITY OF CINCINNATI · PI LI, KEVIN S. · 2013 to 2015
$994k
FDA HHS U01 FD004942FDA HHS U01FD004942
6 · The paper itself

Abstract

introductionExposure to heat can impact the clinical efficacy and/or safety of transdermal and topical drug products. Understanding these heat effects and designing meaningful in vitro and in vivo methods to study them are of significant value to the development and evaluation of drug products dosed to the skin. AREAS COVERED: This review provides an overview of the underlying mechanisms and the observed effects of heat on the skin and on transdermal/topical drug delivery, thermoregulation and heat tolerability. The designs of several in vitro and in vivo heat effect studies and their results are reviewed. EXPERT OPINION: There is substantial evidence that elevated temperature can increase transdermal/topical drug delivery. However, in vitro and in vivo methods reported in the literature to study heat effects of transdermal/topical drug products have utilized inconsistent study conditions, and in vitro models require better characterization. Appropriate study designs and controls remain to be identified, and further research is warranted to evaluate in vitro-in vivo correlations and the ability of in vitro models to predict in vivo effects. The physicochemical and pharmacological properties of the drug(s) and the drug product, as well as dermal clearance and heat gradients may require careful consideration.

Indexed as

Hot TemperatureAdministration, CutaneousAnimalsDrug Delivery SystemsHumansPharmaceutical PreparationsSkinSkin AbsorptionPharmaceutical Preparationsdermal clearanceheat effectheat exposurepatchskin blood flowtopical drug productstransdermal delivery systems (TDS)

Identifiers

PMID26808472
PMCPMC4841791

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.