ArticlePloS one2016
Spectrum of Microbial Diseases and Resistance Patterns at a Private Teaching Hospital in Kenya: Implications for Clinical Practice.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Global trends in macrolide and lincosamide resistance in Streptococcus species: a comprehensive systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Global prevalence of macrolide-resistantFrontiers in microbiology · 2025Pooled it
- Antimicrobial resistance in Africa: a systematic review.BMC infectious diseases · 2017Pooled it
- Outpatient management of urinary tract infections by medical officers in Nairobi, Kenya: lack of benefit from audit and feedback on adherence to treatment guidelines.BMC infectious diseases · 2023Trial
- Article
- Diagnostic Underuse and Antimicrobial Resistance Patterns Among Hospitalized Children in a National Referral Hospital in Kenya: A Five-Year Retrospective Study.Antibiotics (Basel, Switzerland) · 2025Article
- Best Practices in the Management ofTropical medicine and infectious disease · 2024Review
- Prevalence of Antimicrobial Resistance and Association with Patient Outcomes in a Rural Kenyan Hospital.The American journal of tropical medicine and hygiene · 2023Article
- Development of a local antibiogram for a teaching hospital in Ghana.JAC-antimicrobial resistance · 2023Article
- Antimicrobial resistance among bacteria isolated from urinary tract infections in females in Namibia, 2016-2017.Antimicrobial resistance and infection control · 2022Article
- Determination ofJournal of pathogens · 2022Article
- Hospital acquired infections in a private paediatric hospital in Kenya: a retrospective cross-sectional study.The Pan African medical journal · 2022Article
- Antibiogram Development in the Setting of a High Frequency of Multi-Drug Resistant Organisms at University Teaching Hospital, Lusaka, Zambia.Antibiotics (Basel, Switzerland) · 2021Article
- Prevalence, distribution and antimicrobial susceptibility pattern of bacterial isolates from a tertiary Hospital in Malawi.BMC infectious diseases · 2021Article
- Magnitude of Multidrug Resistance among Bacterial Isolates from Surgical Site Infections in Two National Referral Hospitals in Asmara, Eritrea.International journal of microbiology · 2021Article
- Assessment of antimicrobial use and prescribing practices among pediatric inpatients in Zimbabwe.Journal of chemotherapy (Florence, Italy) · 2020Article
- Phenotypic and Genotypic Antibiotic Resistant diarrheagenicEthiopian journal of health sciences · 2020Article
- Microbiological Profile and Drug-Resistance Pattern of Pathogens Among Patients Who Visited the University of Gondar Comprehensive Specialized Hospital, Ethiopia.Infection and drug resistance · 2020Article
- Antimicrobial Resistance in Gram-negative bacteria from Urinary Specimens: a study of prevalence, risk factors and molecular mechanisms of resistance (ARGUS) in Zimbabwe - a study protocol.Wellcome open research · 2020Article
- Staphylococcus aureus bacteremia at a referral medical center in Kenya: A retrospective review of cases from 2010 to 2018.PloS one · 2020Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAccurate local prevalence of microbial diseases and microbial resistance data are vital for optimal treatment of patients. However, there are few reports of these data from developing countries, especially from sub-Saharan Africa. The status of Aga Khan University Hospital Nairobi as an internationally accredited hospital and a laboratory with an electronic medical record system has made it possible to analyze local prevalence and antimicrobial susceptibility data and compare it with other published data.
methodsWe have analyzed the spectrum of microbial agents and resistance patterns seen at a 300 bed tertiary private teaching hospital in Kenya using microbial identity and susceptibility data captured in hospital and laboratory electronic records between 2010 and 2014.
resultsFor blood isolates, we used culture collection within the first three days of hospitalization as a surrogate for community onset, and within that group, Escherichia coli was the most common, followed by Staphylococcus aureus. In contrast, Candida spp. and Klebsiella pneumoniae were the most common hospital onset causes of bloodstream infection. Antimicrobial resistance rates for the most commonly isolated Gram negative organisms was higher than many recent reports from Europe and North America. In contrast, Gram positive resistance rates were quite low, with 94% of S. aureus being susceptible to oxacillin and only rare isolates of vancomycin-resistant enterococci.
conclusionsThe current report demonstrates high rates of antimicrobial resistance in Gram negative organisms, even in outpatients with urinary tract infections. On the other hand, rates of resistance in Gram positive organisms, notably S. aureus, are remarkably low. A better understanding of the reasons for these trends may contribute to ongoing efforts to combat antimicrobial resistance globally.
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