ArticleNature biotechnology2016
Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates.
Erratum issuedOpen access · bronzeAbstract read
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Article in Nature biotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 233 papers.
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233citing papers in PubMed
53.4field-weighted citation impact, top 1% of its field
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233 citing papers in PubMed, 532 citations in OpenAlex.
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- Nanomedicine beyond carriers - devices, cells & living therapeutics.Biomedical microdevices · 2026Review
- Encapsulated Leptin-Producing Cells Facilitate Entrainment of Circadian Rhythms in Rodents and Nonhuman Primates.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Biomaterial-EnabledCell biomaterials · 2026Article
- Localized immunomodulation with cytokine-producing cells to mitigate foreign body responses in rodents and a nonhuman primate.Science advances · 2026Article
- A modular hydrogel system with independent control of bioadhesion, fibrosis, and stiffness.Science advances · 2026Article
- A Facile and Versatile Technique for Creating Antifibrotic Coatings on Biomedical Implants.bioRxiv : the preprint server for biology · 2026Article
- Tissue-bioelectronics interfaces.Chemical Society reviews · 2026Review
- Miniaturized subcutaneous cellular implants for sustained therapeutic protein delivery in resource-limited settings.bioRxiv : the preprint server for biology · 2026Article
- Bandgap-enabled ultrasound tissue marking by a biodegradable metastructured hydrogel implant.Science advances · 2026Article
- Engineering the oxygen microenvironment for pancreatic islet transplants.NPJ Regenerative medicine · 2026Review
- Evaluation of a functionalized chitosan and alginate multilayer conformal nanocoating toward improving islet survival in syngeneic mouse islet transplantation.Bioengineering & translational medicine · 2026Article
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- PiP-Plex: A Particle-in-Particle System for Multiplexed Quantification of Proteins Secreted by Single Cells.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Human donor islets coated with functionalized chitosan and alginate nanoscale layers can restore normoglycemia in diabetic mice.Materials today. Bio · 2026Article
- Clog-free all-aqueous microfluidic fabrication of hydrogel microfibers governed by a universal scaling law.Lab on a chip · 2026Article
- Innate Immune-Cloaked Microgel-Coated Mesenchymal Stromal Cells Reverse Persistent Pulmonary Fibrosis via Reparative Macrophages.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Immune-compatible designs of semiconducting polymers for bioelectronics with suppressed foreign-body response.Nature materials · 2026Article
173 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
35 authors at 6 institutions in 1 country.
Arturo J VegasDavid H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Omid VeisehDavid H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Joshua C DoloffDavid H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Minglin MaDavid H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Hok Hei TamDavid H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Kaitlin BratlieDavid H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.ORCID 0000-0002-5197-0176
Jie LiDavid H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Andrew R BaderDavid H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Erin LanganDavid H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Karsten OlejnikDavid H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Patrick FentonDavid H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Jeon Woong KangMIT Spectroscopy Lab, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Jennifer Hollister-LockeSection on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA.
Matthew A BochenekDepartment of Surgery, Division of Transplantation, University of Illinois at Chicago, Chicago, Illinois, USA.
Alan ChiuDavid H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Sean SiebertDavid H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Katherine TangDavid H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Siddharth JhunjhunwalaDavid H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Stephanie Aresta-DasilvaDavid H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Nimit DholakiaDavid H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Raj ThakrarDavid H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Thema ViettiDavid H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Michael ChenDavid H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.ORCID 0000-0002-1590-768X
Josh CohenSection on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA.
Karolina SiniakowiczSection on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA.
Meirigeng QiDepartment of Surgery, Division of Transplantation, University of Illinois at Chicago, Chicago, Illinois, USA.
James McGarrigleDepartment of Surgery, Division of Transplantation, University of Illinois at Chicago, Chicago, Illinois, USA.
Adam C Graham
Stephen LyleDepartment of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
David M HarlanDiabetes Center of Excellence, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Dale L GreinerDiabetes Center of Excellence, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Jose OberholzerDepartment of Surgery, Division of Transplantation, University of Illinois at Chicago, Chicago, Illinois, USA.
Gordon C WeirSection on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA.
Robert LangerDavid H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Daniel G AndersonDavid H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Boston Children's Hospital · USJoslin Diabetes Center · USMassachusetts Institute of Technology · USUniversity of Illinois Chicago · USUniversity of Massachusetts Chan Medical School · USHarvard University · US
Funding
VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MATTHEW G. VANDER HEIDEN · 1985 to 2026
$93.9MSPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI JEAN E. SCHAFFER · 1986 to 2026
$50.5MThe Development of Clinical Grade, Targeted Magnetic NanoparticlesU54CA151884 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WEISSLEDER, MD, PHD, RALPH · 2010 to 2014
$11.3MWide-Field Short-Wave Infrared (SWIR) multiphoton (MP) tissue imagingP41EB015871 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SO, PETER T. · 2012 to 2021
$11.3MPHOTOPOLYMERIZATION FOR NONINVASIVE CARTILAGE TISSUER01DE013023 · NIDCR · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL · 1998 to 2019
$6.8MCONTROLLED RELEASE OF MACROMOLECULESR01EB000244 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL, TRAVERSO, CARLO GIOVANNI · 2002 to 2021
$6.1MControlled Release of MacromoleculesR37EB000244 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL · 2008 to 2017
$3.9MUltrasound Polymeric Drug DeliveryR01EB000351 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL · 2002 to 2013
$3.0MPhysiological Factors Driving Maturation of Neonatal Beta CellsR01DK093909 · NIDDK · JOSLIN DIABETES CENTER · PI BONNER-WEIR, SUSAN · 2011 to 2015
$1.8MBeta Cell Specific Microfluidic Perifusion and Imaging for Islet Potency TestingR01DK091526 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI OBERHOLZER, JOSE · 2011 to 2015
$1.7MNCI NIH HHS CA151884NCI NIH HHS P30 CA014051NCI NIH HHS P30-CA14051NCI NIH HHS U54 CA151884NIBIB NIH HHS EB000244NIBIB NIH HHS EB000351NIBIB NIH HHS P41 EB015871NIBIB NIH HHS P41EB015871-27NIBIB NIH HHS R01 EB000244NIBIB NIH HHS R01 EB000351NIBIB NIH HHS R37 EB000244NIDCR NIH HHS DE013023NIDCR NIH HHS R01 DE013023NIDDK NIH HHS P30 DK036836NIDDK NIH HHS P30DK036836NIDDK NIH HHS R01 DK091526NIDDK NIH HHS R01DK091526NIDDK NIH HHS R01 DK093909NIDDK NIH HHS R01DK093909
Abstract
The foreign body response is an immune-mediated reaction that can lead to the failure of implanted medical devices and discomfort for the recipient. There is a critical need for biomaterials that overcome this key challenge in the development of medical devices. Here we use a combinatorial approach for covalent chemical modification to generate a large library of variants of one of the most widely used hydrogel biomaterials, alginate. We evaluated the materials in vivo and identified three triazole-containing analogs that substantially reduce foreign body reactions in both rodents and, for at least 6 months, in non-human primates. The distribution of the triazole modification creates a unique hydrogel surface that inhibits recognition by macrophages and fibrous deposition. In addition to the utility of the compounds reported here, our approach may enable the discovery of other materials that mitigate the foreign body response.
Indexed as
AnimalsBiocompatible MaterialsForeign BodiesForeign-Body ReactionHumansHydrogelsMacrophagesPrimatesProstheses and ImplantsBiocompatible MaterialsHydrogels
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.