ArticleNutrition & diabetes2016
Serum S-adenosylmethionine, but not methionine, increases in response to overfeeding in humans.
Article in Nutrition & diabetes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- Epigenetic Changes Associated With Obesity-related Metabolic Comorbidities.Journal of the Endocrine Society · 2025Review
- Role of amino acids in the regulation of hepatic gluconeogenesis and lipogenesis in metabolic dysfunctionassociated steatotic liver disease.Clinical and molecular hepatology · 2025Review
- Differential Impacts of Prenatal Supplement Intake on Childhood Obesity Markers, Stratified by Gender and Other Prenatal Factors.Journal of obesity · 2025Article
- Functional Validation of SAM Riboswitch Element A fromBiochemistry · 2024Article
- Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting.Cell metabolism · 2023Article
- Time-restricted feeding promotes muscle function through purine cycle and AMPK signaling in Drosophila obesity models.Nature communications · 2023Article
- Agri-Food Waste from Apple, Pear, and Sugar Beet as a Source of Protective Bioactive Molecules for Endothelial Dysfunction and Its Major Complications.Antioxidants (Basel, Switzerland) · 2022Review
- Analysis of S-Adenosylmethionine and S-Adenosylhomocysteine: Method Optimisation and Profiling in Healthy Adults upon Short-Term Dietary Intervention.Metabolites · 2022Article
- Rethinking the bioavailability and cellular transport properties of S-adenosylmethionine.Cell stress · 2022Article
- A diagnostic model for overweight and obesity from untargeted urine metabolomics of soldiers.PeerJ · 2022Article
- Epigenetic regulation of energy metabolism in obesity.Journal of molecular cell biology · 2021Review
- Rapid analysis of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) isotopologues in stable isotope-resolved metabolomics (SIRM) using direct infusion nanoelectrospray ultra-high-resolution Fourier transform mass spectrometry (DI-nESI-UHR-FTMS).Analytica chimica acta · 2021Article
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- Mechanism of Activation of Mechanistic Target of Rapamycin Complex 1 by Methionine.Frontiers in cell and developmental biology · 2020Review
- Metabolism and epigenetics of pancreatic cancer stem cells.Seminars in cancer biology · 2019Review
- The impact of dietary protein intake on longevity and metabolic health.EBioMedicine · 2019Review
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlasma concentration of the methyl donor S-adenosylmethionine (SAM) is linearly associated with body mass index (BMI) and fat mass. As SAM is a high-energy compound and a sensor of cellular nutrient status, we hypothesized that SAM would increase with overfeeding.
methodsForty normal to overweight men and women were overfed by 1250 kcal per day for 28 days.
resultsSerum SAM increased from 106 to 130 nmol/l (P=0.006). In stratified analysis, only those with weight gain above the median (high-weight gainers; average weight gain 3.9±0.3 kg) had increased SAM (+42%, P=0.001), whereas low-weight gainers (weight gain 1.5±0.2 kg) did not (Pinteraction=0.018). Overfeeding did not alter serum concentrations of the SAM precursor, methionine or the products, S-adenosyl-homocysteine and homocysteine. The SAM/SAH (S-adenosylhomocysteine) ratio was unchanged in the total population, but increased in high-weight gainers (+52%, P=0.006, Pinteraction =0.005). Change in SAM correlated positively with change in weight (r=0.33, P=0.041) and fat mass (r=0.44, P=0.009), but not with change in protein intake or plasma methionine, glucose, insulin or low-density lipoprotein (LDL)-cholesterol.
conclusionOverfeeding raised serum SAM in proportion to the fat mass gained. The increase in SAM may help stabilize methionine levels, and denotes a responsiveness of SAM to nutrient state in humans. The role of SAM in human energy metabolism deserves further attention.
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