Evidence map›Paper›PMID 26807438›Full record

ArticleACS biomaterials science & engineering2016

Trehalose-Based Block Copolycations Promote Polyplex Stabilization for Lyophilization and in Vivo pDNA Delivery.

Zachary P Tolstyka, Haley Phillips, Mallory Cortez, Yaoying Wu, Nilesh Ingle, Jason B Bell, Perry B Hackett, Theresa M Reineke

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS biomaterials science & engineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 50 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Polymer designChemical science · 2024
    Article
  5. Article
  6. Review
  7. Review
  8. Nucleic Acid Immunotherapeutics for Cancer.ACS applied bio materials · 2020
    Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zachary P TolstykaDepartment of Chemistry and Center for Genome Engineering, University of Minnesota , 207 Pleasant Street SE, Minneapolis, Minnesota 55455, United States.
Haley PhillipsDepartment of Chemistry and Center for Genome Engineering, University of Minnesota , 207 Pleasant Street SE, Minneapolis, Minnesota 55455, United States.
Mallory CortezDepartment of Chemistry and Center for Genome Engineering, University of Minnesota , 207 Pleasant Street SE, Minneapolis, Minnesota 55455, United States.
Yaoying WuDepartment of Chemistry and Center for Genome Engineering, University of Minnesota , 207 Pleasant Street SE, Minneapolis, Minnesota 55455, United States.
Nilesh IngleDepartment of Chemistry and Center for Genome Engineering, University of Minnesota , 207 Pleasant Street SE, Minneapolis, Minnesota 55455, United States.
Jason B BellDepartment of Genetics, Cell Biology and Development, and Center for Genome Engineering, University of Minnesota , Minneapolis, Minnesota 55455, United States.
Perry B HackettDepartment of Genetics, Cell Biology and Development, and Center for Genome Engineering, University of Minnesota , Minneapolis, Minnesota 55455, United States.
Theresa M ReinekeDepartment of Chemistry and Center for Genome Engineering, University of Minnesota , 207 Pleasant Street SE, Minneapolis, Minnesota 55455, United States.
University of Minnesota · US

Funding

THERAPY FOR HYPERAMMONEMIA WITH GENETICALLY ENGINEERED BACTERIAP01HD032652 · NICHD · UNIVERSITY OF MINNESOTA TWIN CITIES · PI WHITLEY, CHESTER B. · 1995 to 2016
$14.5M
Illuminating the Mechanistic Pathways of Polymer-Mediated Nucleic Acid DeliveryDP2OD006669 · OD · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI REINEKE, THERESA M · 2009 to 2010
$2.5M
SB Transposons for Gene TherapyR01DK082516 · NIDDK · UNIVERSITY OF MINNESOTA · PI HACKETT, PERRY B. · 2010 to 2013
$1.3M
Upgrade of a 500 MHz NMR Spectrometer for Applications in Biomedical ResearchS10OD011952 · OD · UNIVERSITY OF MINNESOTA · PI HOYE, THOMAS R. · 2012 to 2012
$378k
NICHD NIH HHS P01 HD032652NIDDK NIH HHS R01 DK082516NIH HHS DP2 OD006669NIH HHS S10 OD011952
6 · The paper itself

Abstract

The development and thorough characterization of nonviral delivery agents for nucleic acid and genome editing therapies are of high interest to the field of nanomedicine. Indeed, this vehicle class offers the ability to tune chemical architecture/biological activity and readily package nucleic acids of various sizes and morphologies for a variety of applications. Herein, we present the synthesis and characterization of a class of trehalose-based block copolycations designed to stabilize polyplex formulations for lyophilization and in vivo administration. A 6-methacrylamido-6-deoxy trehalose (MAT) monomer was synthesized from trehalose and polymerized via reversible addition-fragmentation chain transfer (RAFT) polymerization to yield pMAT

Indexed as

cryo-stabilizationglycopolymerhydrodynamic injectionnanomedicinenanoparticlenonviral gene deliveryRAFT polymerizationstealth polymertransfection

Identifiers

PMID26807438
PMCPMC4710891
OpenAlexW2200197276

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.